Research
CHAN Chung Ngor

Name : CHAN Chung Ngor Juliana  陳重娥
Title :

Professor of Medicine and Therapeutics

Director, Hong Kong Institute of Diabetes and Obesity, CUHK

Director, Diabetes Education and Professional Development Centre, CUHK
Director, Clinical Research Management Office, CUHK

Co-Director, CUHK-PWH International Diabetes Federation Centre of Education

Chief Executive Officer, Asia Diabetes Foundation
Home Department :  Medicine and Therapeutics
Email : jchan@cuhk.edu.hk
Website:  www.idfce-hk.org
  www.adf.org.hk

Biography:

Professor Juliana Chan is a clinician scientist who graduated from The Liverpool University, UK with accreditations in endocrinology and clinical pharmacology. Since joining The CUHK in 1989, she has built up a 60-member multidisciplinary team to discover, disseminate and apply knowledge in the field of diabetes and its co-morbidities in Chinese populations. 

Based on the Hong Kong Diabetes Registry established since 1995, accompanied by a biobank, her team has validated a series of risk equations and discovered a panel of genetic variants predictive of diabetes and its complications in Chinese populations with patents awarded by US-FDA and China SFDA. Her team is now using a multidisciplinary, multiomic, multimethod approach to study the missing heritability of young-onset diabetes and biological significance of novel loci on beta cell and developmental biology. To further address the unmet needs in diabetes, her team has received major grants to study the mechanisms and clinical effectiveness of Chinese Medicine in diabetes and obesity using state of the art methodology. Inspired by the marked benefits of team-based protocol-driven care in clinical trial setting, she has integrated the components of risk stratification and empowerment into a web-based disease Joint Asia Diabetes Evaluation (JADE) Program to translate evidence to practice and evaluate cost-effectiveness of interventions in real settings in Asia. 

She has supervised 50 postgraduate students and scientists and co-authored in over 330 peer reviewed articles and 20 book chapters. She is a member of the NIH-funded Global Consortium to discover diabetes genes, steering committees of multicentre outcome trials, and advisory boards for government and organisations including the World Health Organization and the International Diabetes Federation (IDF), a global advocacy body for people with diabetes. Over the years, her team has set up a CUHK-affiliated multidisciplinary diabetes centre, a community-based nurse-led risk assessment centre and a charitable foundation to translate these discoveries into products/services to benefit the community. 

In 2011, she received the China Women Physicians Association Intercontinental Innovative Award under the Chinese Ministry of Science and Technology. In 2011, the CUHK-PWH Diabetes and Endocrine Centre was selected as one of the 8 IDF Centres of Education for its excellence in professional education and innovative care models. 

Specialised Research Area(s):

Epidemiology, genetics, clinical trials and care models

Selected Publications:

1. Xu, H., Tsang, K. S., Chan, J. C., Yuan, P., Fan, R., Kaneto, H., & Xu, G. (2012). The combined expression of Pdx1 and MafA with either Ngn3 or NeuroD improve the differentiation efficiency of mouse embryonic stem cells into insulin-producing cells. Cell Transplant, [Epub ahead of print]

2. Fan, R., Li, X., Gu, X., Chan, J. C., & Xu, G. (2010). Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis. Diabetes, Obesity and Metabolism, 12(9), 815-824.

3. Kang, Z. F., Deng, Y., Zhou, Y., Fan, R. R., Chan, J. C., Laybutt, D. R., Luzuriage, L., & Xu, G. (2012). In mouse models of diabetes, pharmacological reduction of NEFA restores the efficacy of incretin-based therapies through glucagon-like peptide 1 receptor signalling in the beta cell. Diabetologia (in press).

4. Zhao, H. L., Sui, Y., Qiao, C. F., Yip, K. Y., Leung, R. K., Tsui, S. K., Lee, H. M., Wong, H. K., Zhu, X., Siu, J. J., He, L., Guan, J., Liu, L. Z., Xu, H. X., Tong, P. C., & Chan, J. C. (2012). Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes, 61(4), 933-943

5. Aschner, P., Chan, J., Owens, D. R., Picard, S., Wang, E., Dain, M. P., Pilorget, V., Echtay, A., Fonseca, V., & EASIE investogators. (2012). Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial. Lancet, 379(9833), 2262-2269.


6. Imai, E.,
Chan, J. C., Ito, S., Yamasaki, T., Kobayashi, F., Haneda, M., Makino, H. & ORIENT study investigators. (2011). Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study. Diabetologia, 54(12), 2978-2986.

 

7. So, W. Y., Raboca, J., Sobrepena, L., Yoon, K. H., Deerochanawong, C., Ho, L. T., Himathongkam, T., Tong, P., Lyubomirsky, G., Ko, G., Nan, H., Chan, J. & JADE Program Research Team. (2011). Comprehensive risk assessments of diabetic patients from seven Asian countries: The Joint Asia Diabetes Evaluation (JADE) program. Journal of Diabetes, 3(2), 109-118.

 

8. Ma, R. C., Tam, C. H., Wang, Y., Luk, A. O., Hu, C., Yang, X., Lam, V., Chan, A. W., Ho, J. S., Chow, C. C., Tong, P. C., Jia, W., Ng, M. C., So, W. Y., & Chan, J. C. (2010). Genetic variants of the protein kinase C-beta 1 gene and development of end-stage renal disease in patients with type 2 diabetes. The Journal of the American Medical Assoication, 304(8), 881-889.

 

9. Yang, X., Ko, G. T., So, W. Y., Ma, R. C., Yu, L. W., Kong, A. P., Zhao, H., Chow, C. C., Tong, P. C., & Chan, J. C. (2010). Associations of hyperglycaemia and insulin usage with the risk of cancer in type 2 diabetes: the Hong Kong diabetes registry. Diabetes, 59(5), 1254-1260.

 

10. Ko, G. T., So, W. Y., Tong, P. C., Le Coguiec, F., Kerr, D., Lyubomirsky, G., Tamesis, B., Wolthers, T., Nan, J., & Chan, J. (2010). From design to implementation--the Joint Asia Diabetes Evaluation (JADE) program: a descriptive report of an electronic web-based diabetes management program. BMC Medical Informatics & Decision Making, 10, 26.

 

11. Chan, J. C., Malik, V., Jia, W., Kadowaki, T., Yajnik, C. S., Yoon, K. H., & Hu, F. B. (2009). Diabetes in Asia: epidemiology, risk factors, and pathophysiology. The Journal of the American Medical Assoication, 301(20), 2129-2140.

 

12. Yang, X., Zhao, H., Sui, Y., Ma, R. C., So, W. Y., Ko, G. T., Kong, A. P., Ozaki, R., Yeung, C. Y., Xu, G., Tong, P. C., & Chan, J. C. (2009). Additive interaction between the renin-angiotensin system and lipid metabolism for cancer in type 2 diabetes. Diabetes, 58(7), 1518-1525.


13. Chan, J. C., So, W. Y., Yeung, C. Y., Ko, G. T., Lau, I. T., Tsang, M. W., Lau, K. P., Siu, S. C., Li, J. K., Yeung, V. T., Leung, W. Y., Tong, P. C. & SURE Study Group. (2009). Effects of structured versus usual care on renal endpoint in type 2 diabetes: the SURE study: a randomized multicenter translational study. Diabetes Care, 32(6), 977-982.

 

14. So, W. Y., Wang, Y., Ng, M. C., Yang, X., Ma, R. C., Lam, V., Kong, A. P., Tong, P. C., & Chan, J. C. (2008). Aldose reductase genotypes and cardiorenal complications - an 8-year prospective analysis of 1074 type 2 diabetic patients. Diabetes Care, 31(11), 2148-2153.

 

15. Ng, M. C., Park, K. S., Oh, B., Tam, C. H., Cho, Y. M., Shin, H. D., Lam, V. K., Ma, R. C., So, W. Y., Cho, Y. S., Kim, H. L., Lee, H. K., Chan, J. C., & Cho, N. H. (2008). Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes, 57(8), 2226-2233.

 

16. Wu, J. Y., Leung, W. Y., Chang, S., Lee, B., Zee, B., Tong, P. C., & Chan, J. C. (2006). Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trial. British Medical Journal, 333(7567), 522.

 

17. Ng, M. C., So, W. Y., Cox, N. J., Lam, V. K., Cockram, C. S., Critchley, J. A., Bell, G. I., & Chan, J. C. (2004). Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes, 53(6), 1609-1613.

 

18. Ng, M. C., Lee, S. C., Ko, G. T., Li, J. K., So, W. Y., Hashim, Y., Barnett, A. H., Mackay, I. R., Critchley, J. A., Cockram, C. S., & Chan, J. C. (2001). Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles of than autoimmunity. Diabetes Care, 24(4), 663-671.