Research
HUANG Yu
Name : HUANG Yu 黃聿
Title :

Director (Basic Sciences), Institute of Vascular Medicine

Professor, School of Biomedical Sciences
Home Department :  School of Biomedical Sciences
Email : yu-huang@cuhk.edu.hk
Phone Number:  (852) 3943 6787
Website of Lab: http://www.cuhk.edu.hk/proj/HuangLab
PI's Website: http://www.sbs.cuhk.edu.hk/TeachingStaffDetails.asp?TE_NAME=HUANG Yu    

Biography:

B.Sc, Shanghai First Medical College (Fudan University Shanghai Medical College since 2002)
M.Phil., Ph.D., University of Cambridge, England (Sept 1984- Feb 1988)
Postdoctoral Fellow, University of Vermont, USA (Feb 1988- July 1991)
Postdoctoral Physiologist, University of California at Los Angeles, USA (July 1991- Sept 1993)  

Specialised Research Area(s):

Vascular Biology and Medicine; Endothelial Cell Dysfunction and Novel Biomarkers in Diabetes, Hypertension and Estrogen Deficiency; Role of Adipose Tissue in the Regulation of Vascular Function; and  Hypotensive and Antioxidant Actions of Natural Products

Selected Publications:

1. Tian XY, Wong WT, Wang NP, Lu Y, Cheang WS, Liu J, Liu LM, Liu YH, Lee SST, Chen ZY, Cooke JP, Yao XQ, Huang Y. Ppar delta activation protects endothelial function in diabetic mice. Diabetes 2012; 61: 3285-3293.

2. Dong JH, Wong SL, Lau CW, Lee HK, Ng CF, Zhang LH, Yao XQ, Chen ZY, Vanhoutte PM, Huang Y. Calcitriol protects renovascular function in hypertension by down-regulating angiotensin ii type 1 receptors and reducing oxidative stress. European Heart Journal 2012; 33: 2980-2990.

3. Yuen CY, Wong SL, Lau CW, Tsang SY, Xu AM, Zhu ZM, Ng CF, Yao XQ, Kong SK, Lee HK, Huang Y. From skeleton to cytoskeleton osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin ii and toll-like receptor 4. Circulation Research 2012; 111: E55-E66.

4. Tian XY, Wong WT, Xu AM, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao XQ, Huang Y. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circulation Research 2012; 110: 1211-1126.

5. Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao XQ, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y. Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f-2 alpha impairs endothelial function in renovascular hypertensive rats. Antioxidants & Redox Signaling 2012; 16: 363-373.

6. Wong Wing T, Tian Xiao Y, Xu A, Yu J, Lau Chi W, Hoo Ruby LC, Wang Y, Lee Vivian WY, Lam Karen SL, Vanhoutte Paul M, Huang Y. Adiponectin is required for pparγ-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 2011; 14: 104-115.

7. Wong WT, Tian XY, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu AM, Yao XQ, Vanhoutte PM, Tipoe GL, Huang Y. Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation implications on hypertension. Circulation Research 2010; 107: 984-991.

8. Wong SL, Leung FP, Lau CW, Au CL, Yung LM, Yao XQ, Chen ZY, Vanhoutte PM, Gollasch M, Huang Y. Cyclooxygenase-2-derived prostaglandin f-2 alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circulation Research 2009; 104: 228-235.