Research
LAM, Wai Kei Jacky

Name : LAM, Wai Kei Jacky  林偉棋
Title :

Assistant Professor
Home Department :  Department of Chemical Pathology
Email : jwaikeilam@cuhk.edu.hk
Website:  https://www.cuhk.edu.hk/med/cpy/Research/JackyLam.htm


 

Biography:

Dr. Jacky Lam is the Assistant Professor of the Department of Chemical Pathology and an honorary associate consultant at the Prince of Wales Hospital. Dr. Lam obtained his medical degree in 2007 and received his Ph.D. in Chemical Pathology from the Chinese University of Hong Kong in 2020. His research interests are on the biological features of plasma DNA and its potential clinical application in noninvasive cancer detection. He is involved in a large-scale prospective clinical study using plasma Epstein-Barr virus DNA for screening of nasopharyngeal carcinoma. This study laid the foundation for the clinical utility of plasma Epstein-Barr virus DNA analysis for cancer screening. Based on this study, he has further investigated the distinct molecular features of plasma Epstein-Barr virus DNA in nasopharyngeal cancer. Such discoveries have led to the development of novel diagnostic assays which allows better differentiation of patients with nasopharyngeal cancer and non-cancer subjects in the context of screening.


 

Specialised Research Area(s):

  • Non-invasive cancer diagnostic approaches
  • Biology of circulating nucleic acids
  • Nasopharyngeal cancer diagnostics

Selected Publications:

1. YMD Lo and WKJ Lam. Towards multi-cancer screening using liquid biopsies. Nature Reviews Clinical Oncology. 2020;17:525-526.

2. WKJ Lam, L Ji, OYO Tse, SH Cheng, P Jiang, PHP Lee, SV Lin, EP Hui, BBY Ma, ATC Chan, KCA Chan, RWK Chiu, YMD Lo. Sequencing analysis of plasma Epstein-Barr virus DNA reveals nasopharyngeal carcinoma-associated single nucleotide variant profiles. Clinical Chemistry. 2020;66(4):598-605.

3. WKJ Lam, P Jiang, KCA Chan, W Peng, H Shang, MMS Heung, SH Cheng, H Zhang, OYO Tse, R Raghupathy, BBY Ma, EP Hui, ATC Chan, JKS Woo, RWK Chiu, YMD Lo. Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases. Nature Communications. 2019;10(1):3256.

4. WKJ Lam, KCA Chan and YMD Lo. Plasma Epstein-Barr virus DNA as an archetypal circulating tumour DNA marker. Journal of Pathology. 2019;247:641-649.

5. W Gai, L Ji, WKJ Lam, K Sun, P Jiang, AWH Chan, J Wong, PBS Wong, SSM Ng, BBY Ma, GLH Wong, VWS Wong, HLY Chan, RWK Chiu, YMD Lo, KCA Chan. Liver- and colon- specific DNA methylation markers in plasma for investigation of colorectal cancers with or without liver metastases. Clinical Chemistry. 2018;64(8):1239-1249.

6. WKJ Lam, P Jiang, KCA Chan, SH Cheng, H Zhang, W Peng, OYO Tse, YK Tong, W Gai, BCY Zee, BBY Ma, EP Hui, ATC Chan, JKS Woo, RWK Chiu, YMD Lo. Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(22):E5115-E2124.

7. KCA Chan, JKS Woo, A King, BCY Zee, WKJ Lam, SL Chan, SWI Chu, C Mak, IOL Tse, SYM Leung, G Chan, EP Hui, BBY Ma, RWK Chiu, S Leung, AC van Hasselt, ATC Chan, YMD Lo. Analysis of plasma Epstein-Barr virus DNA to screen for nasopharyngeal carcinoma. New England Journal of Medicine. 2017;377(6):513-522.

8. WKJ Lam, W Gai, K Sun, RSM Wong, RWY Chan, P Jiang, NPH Chan, WWI Hui, AWH Chan, CC Szeto, SC Ng, MF Law, KCA Chan, RWK Chiu, YMD Lo. DNA of erythroid origin is present in human plasma and informs the types of anemia. Clinical Chemistry. 2017;63(10):1614-1623.

9. YMD Lo and WKJ Lam. Tracing the tissue of origin of plasma DNA – feasibility and implications. Marrow, Annals of the New York Academy of Sciences. 2016;1376(1):14-17.