Research
LAN Hui-yao
Name : LAN Hui-yao 藍輝耀
Title : Assistant Dean (Research), Faculty of Medicine
Professor of Biomedical Sciences
Choh-Ming Li Professor of Biomedical Sciences
Home Department :  Medicine and Therapeutics
Email : hylan@cuhk.edu.hk
Phone Number: 
(852) 3763 6077
Fax Number:
(852) 2145 7190
Address: Room 601, Li Ka Shing Medical Sciences Building, Prince of Wales Hospital, Shatin, N.T., Hong Kong

Biography:

Professor Hui Yao LAN is a Choh-Ming Li  Professor of Biomedical Sciences jointly at the Department of Medicine & Therapeutics, and the Li Ka Shing Institute of Health Sciences, as well as Professor (by courtesy) in the  School of Biomedical Sciences and the Department of Anatomical and Cellular Pathology, the Chinese University of Hong Kong. Professor Lan received his Medical (1977) and Master degree (1986) at Sun Yat-Sen University of Medical Sciences,China and PhD degree (1990) at Monash University, Australia. He previously held a tenured full professorship at the Department of Medicine, Baylor College of Medicine, Houston, USA and full Professorship at the Department of Medicine, the University of Hong Kong. He has been servicing as an Editorial board member in many scientific journals and published more than 280 peer-reviewed papers with h-index over 60.

Specialised Research Area(s):

The TGF-beta/Smad signaling in tissue fibrosis, inflammation, and cancer microenvironments.

Selected Publications:

1. Wang WS, Huang XR, Canlas E, Oka K, Truong LD, Deng CX, Bhowmick NA, Ju WJ, Bottinger EP, Lan HY. Essential role of smad3 in angiotensin ii-induced vascular fibrosis. Circulation Research 2006; 98: 1032-1039.

2. Koka V, Wang WS, Huang XR, Kim-Mitsuyama S, Truong LD, Lan HY. Advanced glycation end products activate a chymase-dependent angiotensin ii-generating pathway in diabetic complications. Circulation 2006; 113: 1353-1360.

3. Meng XM, Huang XR, Chung ACK, Qin W, Shao XL, Igarashi P, Ju WJ, Bottinger EP, Lan HY. Smad2 protects against tgf-beta/smad3-mediated renal fibrosis. Journal of the American Society of Nephrology 2010; 21: 1477-1487.

4. Chung ACK, Huang XR, Meng XM, Lan HY. Mir-192 mediates tgf-beta/smad3-driven renal fibrosis. Journal of the American Society of Nephrology 2010; 21: 1317-1325.

5. Zhong X, Chung ACK, Chen HY, Meng XM, Lan HY. Smad3-mediated upregulation of mir-21 promotes renal fibrosis. Journal of the American Society of Nephrology 2011; 22: 1668-1681.

6. Zhong, X., Chung, A. C., Chen, H. Y., Meng, X. M., & Lan, H. Y. (2011). Smad3-mediated upregulation of miR-21 promotes renal fibrosis. Journal American Society of Nephrololy, 22(9),1668-1681.

7. Qin W, Chung ACK, Huang XR, Meng XM, Hui DSC, Yu CM, Sung JJY, Lan HY. Tgf-beta/smad3 signaling promotes renal fibrosis by inhibiting mir-29. Journal of the American Society of Nephrology 2011; 22: 1462-1474.

8. Chung ACK, Dong Y, Yang WQ, Zhong X, Li R, Lan HY. Smad7 suppresses renal fibrosis via altering expression of tgf-beta/smad3-regulated micrornas. Molecular Therapy 2013; 21: 388-398.

9. Chen HY, Zhong X, Huang XR, Meng XM, You YK, Chung ACK, Lan HY. Microrna-29b inhibits diabetic nephropathy in db/db mice. Molecular Therapy 2014; 22: 842-853.

10. Zhou Q, Huang XR, Yu JW, Yu XQ, Lan HY. Long noncoding rna arid2-ir is a novel therapeutic target for renal inflammation. Molecular Therapy 2015; 23: 1034-1043.