Research
LAN Hui-yao
Name : LAN Hui-yao 藍輝耀
Title : • Associate Dean Mainland Affairs, Faculty of Medicine
• Associate Director, Li Ka Shing Institute of Health Sciences
• Chon-Ming Li Professor of Biomedical Sciences
Home Department :  Medicine and Therapeutics
Email : hylan@cuhk.edu.hk
Phone Number: 
 (852) 3763 6077
Fax Number:
 (852) 2145 7190
Address: Room 601, Li Ka Shing Medical Sciences Building,
Prince of Wales Hospital, Shatin, N.T., Hong Kong

Biography:

Professor Hui Yao LAN is a Choh-Ming Li  Professor of Biomedical Sciences jointly at the Department of Medicine & Therapeutics, and the Li Ka Shing Institute of Health Sciences, as well as Professor (by courtesy) in the  School of Biomedical Sciences and the Department of Anatomical and Cellular Pathology, the Chinese University of Hong Kong. Professor Lan received his Medical (1977) and Master degree (1986) at Sun Yat-Sen University of Medical Sciences,China and PhD degree (1990) at Monash University, Australia. He previously held a tenured full professorship at the Department of Medicine, Baylor College of Medicine, Houston, USA and full Professorship at the Department of Medicine, the University of Hong Kong. He has been servicing as an Editor/Associate Editor and Editorial board member in many scientific journals and published more than350eer-reviewed papers with h-index 95.

Specialised Research Area(s):

The TGF-beta/Smad signaling in tissue fibrosis, inflammation, and cancer microenvironments.

Selected Publications:

1. Wang WS, Huang XR, Canlas E, Oka K, Truong LD, Deng CX, Bhowmick NA, Ju WJ, Bottinger EP, Lan HY. Essential role of smad3 in angiotensin ii-induced vascular fibrosis. Circulation Research 2006; 98: 1032-1039.

2. Koka V, Wang WS, Huang XR, Kim-Mitsuyama S, Truong LD, Lan HY. Advanced glycation end products activate a chymase-dependent angiotensin ii-generating pathway in diabetic complications. Circulation 2006; 113: 1353-1360.

3. Meng XM, Huang XR, Chung ACK, Qin W, Shao XL, Igarashi P, Ju WJ, Bottinger EP, Lan HY. Smad2 protects against tgf-beta/smad3-mediated renal fibrosis. Journal of the American Society of Nephrology 2010; 21: 1477-1487.

4. Zhong X, Chung ACK, Chen HY, Meng XM, Lan HY. Smad3-mediated upregulation of mir-21 promotes renal fibrosis. Journal of the American Society of Nephrology 2011; 22: 1668-1681.

5. Qin W, Chung ACK, Huang XR, Meng XM, Hui DSC, Yu CM, Sung JJY, Lan HY. Tgf-beta/smad3 signaling promotes renal fibrosis by inhibiting mir-29. Journal of the American Society of Nephrology 2011; 22: 1462-1474.

6. Chen HY, Zhong X, Huang XR, Meng XM, You YK, Chung ACK, Lan HY. Microrna-29b inhibits diabetic nephropathy in db/db mice. Molecular Therapy 2014; 22: 842-853.

7. Tang PM, Zhou S, Meng XM, Wang QM, Li CJ, Lian GY, Huang XR, Tang YJ, Guan XY, Yan BP, To KF, Lan HY. Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development. Nature Communications. 2017;8:14677.

8. Feng M, Tang PM, Huang XR, Sun SF, You YK, Xiao J, Lv LL, Xu AP, Lan HY. TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis. Molecular Therapy. 2018;26:148-161.

8. Feng M, Tang PM, Huang XR, Sun SF, You YK, Xiao J, Lv LL, Xu AP, Lan HY. TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis. Molecular Therapy. 2018;26:148-161.

9. Wang QM, Tang PM, Lian GY, Li C, Li J, Huang XR, To KF, Lan HY. Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells. Cancer Immunology Research. 2018;6:965-977.
10. Tang PM, Nikolic-Paterson DJ, Lan HY. Macrophages: versatile players in renal inflammation and fibrosis. Nature Reviews Nephrology. 2019; 15:144-158.