Research
LI Gang
Name : LI Gang 李剛
Title : Professor (non-clinical)
Home Department :  Orthopaedics and Traumatology
Li Ka Shing Institute of Health Sciences
SMART Program, Institute of Innovative Medicine
CUHK Shenzhen Research Institute 
Email : gangli@cuhk.edu.hk
Phone Number:
(852) 3763 6153 
Fax Number:
(852) 2637 7889
Address: Room 904, Li Ka Shing Medical Sciences Building, Prince of Wales Hospital, Shatin, N.T., Hong Kong

Biography:

Dr. Gang Li received his MBBS degree from The 4th Military Medical University, Xian, China (1985-1991), and served as a military surgeon in Beijing 301 Hospital (1991-1993) before he moved to England in 1993. He graduated from University of Oxford Medical School (1997) with a D.Phil. degree on studies of biological mechanisms of distraction osteogenesis. After post-doctoral training at the Medical Research Council Bone Research Laboratory in The University of Oxford, he took up a lectureship (1998), Senior Lectureship (2001) and Readership (2004) in the School of Medicine, Queen's University Belfast, Belfast, United Kingdom.  Dr. Li is currently a full Professor at The Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong (2009-). He also serves as Deputy chief of Stem Cells and Regeneration Program, School of Biomedical Sciences, CUHK and Deputy Director of Space Medicine Laboratory, CUHK Shenzhen Research Institute. His main research interests are on biological mechanisms of distraction osteogenesis, fracture healing, musculoskeletal tissue regeneration, stem cell biology and gene therapy. He has published more than 100 peer-reviewed papers, 10 book chapters, and edited 3 books.  His work has been cited for more than 3000 times with a H-index of 25; he has been invited to give keynote lectures, seminars on stem cells biology, tissue engineering and regenerative medicine in USA, Japan, Australia, Russia, Europe, China, Taiwan, etc for numerous occasions.  He serves as Life member and General secretary (2013-) of International Chinese Musculoskeletal Research Society; Honorary Treasurer of British Orthopaedic Research Society (2004-2006); Member of Program Committee of American Orthopaedic Research Society (2006-2007) and a Member of Editorial Board, Calcified Tissue International (2004-) and Associated Editor, Journal of Orthopaedic Translation (2013-). He currently serves as the general secretary of Limb Reconstruction Society, Chinese Association of Orthopaedic Surgeons; council member of Chinese Orthopaedic Research Society, Chinese Medical Association; council member of Tissue Engineering and Regenerative Medicine Society, Chinese Association of Biomedical Engineering. He is an active member of ASBMR, ORS, ISCT and ICMRS. Dr. Li also holds honorary Professorship at China Medical University, Shenyang; Shanxi Medical University; South-East University, Nanjing; The Fourth Military Medical University, Xian; Guang Dong Medical College.

Specialised Research Area(s):

Circulating mesenchymal stem cells (MSCs) biology, homing and recruitment mechanisms;

Novel genes control stem cell differentiation and migration;

Stem cell gene therapy (the use of MSCs as anti-cancer vehicles);

Tissue engineering for musculoskeletal tissues (fracture repair, tendon disorder, distraction osteogenesis and cartilage repair).

Selected Publications:

1. Rui YF, Xu LL, Chen R, Zhang T, Lin S, Hou YH, Liu Y, Meng FB, Liu ZQ, Ni M, Tsang KS, Yang FY, Wang C, Chan HC, Jiang XH, Li G. Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells. Scientific Reports 2015; 5.

2. Xu LL, Huang S, Hou YH, Liu Y, Ni M, Meng FB, Wang KX, Rui YF, Jiang XH, Li G. Sox11-modified mesenchymal stem cells (mscs) accelerate bone fracture healing: Sox11 regulates differentiation and migration of mscs. Faseb Journal 2015; 29: 1143-1152.

3. Wang KX, Xu LL, Rui YF, Huang S, Lin SE, Xiong JH, Li YH, Lee WYW, Li G. The effects of secretion factors from umbilical cord derived mesenchymal stem cells on osteogenic differentiation of mesenchymal stem cells. Plos One 2015; 10; 3.

4. Li N, Lee WYW, Lin SE, Ni M, Zhang T, Huang XR, Lan HY, Li G. Partial loss of smad7 function impairs bone remodeling, osteogenesis and enhances osteoclastogenesis in mice. Bone 2014; 67: 46-55. 

5. Meng FB, Rui YF, Xu LL, Wan C, Jiang XH, Li G. Aqp1 enhances migration of bone marrow mesenchymal stem cells through regulation of fak and beta-catenin. Stem Cells Dev 2014; 23: 66-75.

6. Lee WYW, Zhang T, Lau CPY, Wang CC, Chan K-M, Li G. Immortalized human fetal bone marrow-derived mesenchymal stromal cell expressing suicide gene for anti-tumor therapy in vitro and in vivo. Cytotherapy 2013; 15: 1484-1497.

7. Ni M, Rui YF, Tan Q, Liu Y, Xu LL, Chan KM, Wang Y, Li G. Engineered scaffold-free tendon tissue produced by tendon-derived stem cells. Biomaterials 2013; 34: 2024-2037.

8. Fan QM, Yue B, Bian ZY, Xu WT, Tu B, Dai KR, Li G, Tang TT. The creb-smad6-runx2 axis contributes to the impaired osteogenesis potential of bone marrow stromal cells in fibrous dysplasia of bone. Journal of Pathology 2012; 228: 45-55. 

9. Song C, Xiang JJ, Tang JQ, Hirst DG, Zhou JW, Chan KM, Li G. Thymidine kinase gene modified bone marrow mesenchymal stem cells as vehicles for antitumor therapy. Human Gene Therapy 2011; 22: 439-449.

10. Yang ZQ, Shi YY, Wei XC, He JR, Yang SH, Dickson G, Tang JQ, Xiang JJ, Song C, Li G. Fabrication and repair of cartilage defects with a novel acellular cartilage matrix scaffold. Tissue Engineering Part C-Methods 2010; 16: 865-876.