QIN, Ling

Name :

QIN, Ling 秦嶺

Title :

Assistant Dean (Mainland Affairs), Faculty of Medicine
Professor and Director of Musculoskeletal Research Laboratory
Division Head of Postgraduate Studies, Department of Orthopaedics and Traumatology
Director of Bone Quality and Health Center of the Chinese University of Hong Kong

Home Department :

Department of Orthopaedics and Traumatology

Email :

lingqin@cuhk.edu.hk

Office Phone Number:

(852) 3505 3071

Website :

www.ort.cuhk.edu.hk/staff-qinling.html

Biography:

Professor Qin is Professor and Director of Musculoskeletal Research Laboratory in the Department of Orthopaedics & Traumatology, the Chinese University of Hong Kong. Professor Qin also holds joint professorship in Shenzhen Institutes of Advance Technology (SIAT) of Chinese Academy of Sciences (CAS) and serves Director of the Translational Medicine Research & Development Center of Institute of Biomedical & Health Engineering of SIAT (http://www.siat.cas.cn). He received his BA and M.Phil. in basic medical and life sciences in physical education at the Beijing Sports University in China, and his PhD from German Sports University, Cologne, Germany and postdoctoral training in AO-Research Institute, Davos, Switzerland. Professor Qin was research scientist in the Department of Trauma & Reconstructive Surgery, University Clinic Rudolf Virchow, Free University Berlin (now known as Charite Medical University) Germany before joining CUHK in late 1994.

Professor Qin is the past President of the International Chinese Musculoskeletal Research Society (ICMRS) (http://www.icmrs.net) and member of a number of journal editorial boards, including Editor-in-chief of Journal of Orthopaedic Translation (http://www.e-jot.com); Associate Editor of Clinical Biomechanics and Chinese Journal of Orthopaedic Surgery; board member of a number of international journals, including Journal of Bone and Mineral Research (http://www.jbmr.org) and International Journal of Sports Medicine (http://www.thieme.de/sportsmed). He holds memberships in several international and national orthopaedic and related research organizations, including collage fellow of American Institute of Medical and Biological Engineering (http://www.aimbe.org). He has received over 40 Research Awards and holds 10 patents.

Professor Qin published 10 monographs as editor or associate editor, 5 conference proceedings, 80 book chapters, and over 400 journal papers in English, German, and Chinese, including around 340 SCI articles published in Nat Med, Nat Comm, Adv Sci, ARD, JBMR, Osteoporosis Int, Bone, A&R, Biomaterials, Acta Biomaterialia, Am J Sports Med, Int J Sports Med, etc. with citation >9000 and a H-index of 52.

Specialised Research Area(s):

1) Diagnosis, prevention and treatment of skeletal degenerative disorders, including osteoporosis and osteonecrosis.

2) Research and development of pharmaceutical agents (nature products from herbs and minerals) and physical means (exercises and biophysical modalities) for prevention of age-related neuromusculoskeletal degeneration and healing enhancement.

Selected Publications:

1. Zheng L-Z, Wang J-L, Xu J-K, Zhang X-T, Liu B-Y, Huang L, Zhang R, Zu H-Y, He X, Mi J, Pang Q-Q, Wang X-L, Ruan YC, Zhao D-W, Qin L. Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model. Biomaterials. 2020 Apr;238:119828.

2. Wang J-L, Xu J-K, Hopkins C, Chow DHK, Qin L. Biodegradable Magnesium-Based Implants in Orthopedics—A General Review and Perspectives. Advanced Science.; 2020 Jan 1;11:1902443.

3. Tong W, Zeng Y, Chow DHK, Yeung W, Xu J, Deng Y, Chen S, Zhao H, Zhang X, Ho KK, Qin L, Mak KK-L. Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade. Annals of the Rheumatic Diseases. 2019 Apr;78(4):551–61.

4. Feng Q, Xu J, Zhang K, Yao H, Zheng N, Zheng L, Wang J, Wei K, Xiao X, Qin L, Bian L. Dynamic and Cell-Infiltratable Hydrogels as Injectable Carrier of Therapeutic Cells and Drugs for Treating Challenging Bone Defects. ACS Central Science. 2019 Mar 27;5(3):440–50. PMCID: PMC6439455.

5. Huang L, Wang X, Cao H, Li L, Chow DHK, Tian L, Wu H, Zhang J, Wang N, Zheng L, Yao X, Yang Z, Qin L. A bone-targeting delivery system carrying osteogenic phytomolecule icaritin prevents osteoporosis in mice. Biomaterials. 2018 Nov;182:58–71.

6. Wang J, Wu Y, Li H, Liu Y, Bai X, Chau W, Zheng Y, Qin L. Magnesium alloy based interference screw developed for ACL reconstruction attenuates peri-tunnel bone loss in rabbits. Biomaterials. 2018 Mar;157:86–97.

7. Wang J, Xu J, Song B, Chow DHK, Shu-Hang Yung P, Qin L. Magnesium (Mg) based interference screws developed for promoting tendon graft incorporation in bone tunnel in rabbits. Acta Biomaterialia. 2017 Nov;63:393–410.

8. Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DHK, Xie X, Zheng L, Huang L, Huang S, Leung K, Lu N, Zhao L, Li H, Zhao D, Guo X, Chan K, Witte F, Chan HC, Zheng Y, Qin L. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nature Medicine. 2016 Oct;22(10):1160–9.

9. Qin L, Yao D, Zheng LZ, Liu WC, Liu Z, Lei M, Huang L, Xie XH, Wang XL, Chen Y, Yao XS, Peng J, Gong H, Griffith JF, Huang YP, Zheng YP, Feng JQ, Liu Y, Chen SH, Xiao DM, Wang DP, Xiong JY, Pei DQ, Zhang P, Pan XH, Wang XH, Lee KM, CY Cheng. Phytomolecule Icaritin Incorporated PLGA/TCP Scaffold for Steroid-Associated Osteonecrosis: Proof-of-Concept for Prevention of Hip Joint Collapse in Bipedal Emus and Mechanistic Study in Quadrupedal Rabbits. Biomaterials, 59:125-43, 2015.

10. Zhu HM*, Qin L, Garnero P, Genant HK, Zhang G, Dai K, Yao X, Gu G, Hao Y, Li Z, Zhao Y, Li W, Shi D, Fuerst T, Lu Y, Li H, Zhang X, Li C, Zhao J, Wu Q, Zhao SJ.et al. The First Multicenter and Randomized Clinical Trial of Herbal Fufang for Treatment of Postmenopausal Osteoporosis. Osteoporosis Int 23(4), 1317-27, 2012.

11. Xie XH, Wang XL, He YX, Liu Z, Sheng H, Zhang G*, Qin L. Promoted repair of steroid-associated osteonecrosis by implantation of cryopreserved bone marrow mononuclear cells in a rabbit model. Arthritis Rheum 64(5):1562-71, 2012.

12. Zhang G, Guo BS, Wu H, Tang T, Zhang BT, ZhengLZ, He YX, Yang ZJ, Pan XH, Chow H, To K, Li YP, Li DH, Wang XL, Wang YX, Lee K, Hou ZB, Dong N, Li G, Leung K, Hung LK, He FC, Zhang LQ, Qin L. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine 18(2): 307-14, 2012.

13. Xie XH, Wang XL, Zhang G, He YX, Wang XH, Liu Z, He K, Peng J, Leng Y, Qin L*. Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular Icaritin. Biomed Mater 5(5):054109, 2010.

14. Wang L, Qin L, Lu HB, Cheung WH, Yang H, Wong WN, Chan KM, Leung KS. Extracorporeal shockwave therapy in treatment of delayed bone-tendon healing. American Journal of Sports Medicine 36(2):340-7, 2008.

15. Zhang G, Qin L*, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. Journal Of Bone And Mineral Research 22: 1072-9, 2007

16. Qin L*, Lu HB, Fok PK, Cheung WC, Zheng YP, KM Lee, Leung KS. Low intensity pulsed ultrasound accelerates osteogenesis at bone-tendon junction healing junction. Ultrasound in Medicine and Biology 32(12): 1905-1911, 2006.

17. Fan HB, Hu YY, Zhang C, Li X, Lv R, Qin L, Zhu R. Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold. Biomaterials, 27:4573-4580, 2006.

Books

1. 秦嶺（主編）：骨內科學人民衛生出版社) Qin L. Orthopaedci Medicine (in Chinese. Peoples’ Medical Publishing House (ISBN 978-7-117-18088-7/R·18089; Total 800 pages and 460 figures 2013.

2. Leung KS, Qin YX, Cheung WH, Qin L*. A Practical Manual for Musculoskeletal Research. World Scientific 2008.

3. Qin L*, Genant HK, Leung KS, Griffith FJ. (eds). Advanced Bioimaging Technologies in Assessment of Quality of Bone and Scaffold Biomaterials. Springer Verlag 2007.