Research
QIN, Ling
Name : QIN, Ling 秦嶺
Title :
Professor and Director of Musculoskeletal Research Laboratory
Director of Bone Quality and Health Center of the Chinese University of Hong Kong
Home Department :  Department of Orthopaedics and Traumatology
Email : lingqin@cuhk.edu.hk
Office Phone Number: (852) 3505 3071
Website :
http://www.ort.cuhk.edu.hk/staff-qinling.html

Biography:

Professor Qin is Professor and Director of Musculoskeletal Research Laboratory in the Department of Orthopaedics & Traumatology, the Chinese University of Hong Kong. Professor Qin also holds joint professorship in Shenzhen Institutes of Advance Technology (SIAT) of Chinese Academy of Sciences (CAS) and serves Director of the Translational Medicine Research & Development Center of Institute of Biomedical & Health Engineering of SIAT (http://www.siat.cas.cn). He received his BA and M.Phil. in basic medical and life sciences in physical education at the Beijing Sports University in China, and his PhD from German Sports University, Cologne, Germany and postdoctoral training in AO-Research Institute, Davos, Switzerland. Professor Qin was research scientist in the Department of Trauma & Reconstructive Surgery, University Clinic Rudolf Virchow, Free University Berlin (now known as Charite Medical University) Germany before joining CUHK in late 1994.


Prof. Qin has been the editor of 8 books and has published 3 Theses, 88 Book Chapters, more than 280 SCI papers with over 6000 citations and H-Index over 44.
 

Specialised Research Area(s):

1) Diagnosis, prevention and treatment of skeletal degenerative disorders, including osteoporosis and osteonecrosis.

2) Research and development of pharmaceutical agents (nature products from herbs and minerals) and physical means (exercises and biophysical modalities) for prevention of age-related neuromusculoskeletal degeneration and healing enhancement.

 

Selected Publications:

1. Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DHK, Xie X, Zheng L, Huang L, Huang S, Leung K, Lu N, Zhao L, Li H, Zhao D, Guo X, Chan K, Witte F, Chan HC, Zheng Y, Qin L*. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nat Med. 2016 Oct;22(10):1160–9. 

2. Qin L*, Yao D, Zheng LZ, Liu WC, Liu Z, Lei M, Huang L, Xie XH, Wang XL, Chen Y, Yao XS, Peng J, Gong H, Griffith JF, Huang YP, Zheng YP, Feng JQ, Liu Y, Chen SH, Xiao DM, Wang DP, Xiong JY, Pei DQ, Zhang P, Pan XH, Wang XH, Lee KM, CY Cheng. Phytomolecule Icaritin Incorporated PLGA/TCP Scaffold for Steroid-Associated Osteonecrosis: Proof-of-Concept for Prevention of Hip Joint Collapse in Bipedal Emus and Mechanistic Study in Quadrupedal Rabbits. Biomaterials, 59:125-43, 2015.

3. Zhu HM*, Qin L*, Garnero P, Genant HK, Zhang G, Dai K, Yao X, Gu G, Hao Y, Li Z, Zhao Y, Li W, Shi D, Fuerst T, Lu Y, Li H, Zhang X, Li C, Zhao J, Wu Q, Zhao SJ.et al. The First Multicenter and Randomized Clinical Trial of Herbal Fufang for Treatment of Postmenopausal Osteoporosis. Osteoporosis Int 23(4), 1317-27, 2012.

4. Xie XH, Wang XL, He YX, Liu Z, Sheng H, Zhang G*, Qin L*. Promoted repair of steroid-associated osteonecrosis by implantation of cryopreserved bone marrow mononuclear cells in a rabbit model. Arthritis Rheum 64(5):1562-71, 2012.

5. Zhang G, Guo BS, Wu H, Tang T, Zhang BT, ZhengLZ, He YX, Yang ZJ, Pan XH, Chow H, To K, Li YP, Li DH, Wang XL, Wang YX, Lee K, Hou ZB, Dong N, Li G, Leung K, Hung LK, He FC, Zhang LQ, Qin L*. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine 18(2): 307-14, 2012.

6. Xie XH, Wang XL, Zhang G, He YX, Wang XH, Liu Z, He K, Peng J, Leng Y, Qin L*. Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular Icaritin. Biomed Mater 5(5):054109, 2010.

7. Wang L, Qin L*, Lu HB, Cheung WH, Yang H, Wong WN, Chan KM, Leung KS. Extracorporeal shockwave therapy in treatment of delayed bone-tendon healing. Am J Sports Med 36(2):340-7, 2008

8. Zhang G, Qin L*, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone Miner Res 22: 1072-9, 2007

9. Qin L*, Lu HB, Fok PK, Cheung WC, Zheng YP, KM Lee, Leung KS. Low intensity pulsed ultrasound accelerates osteogenesis at bone-tendon junction healing junction. Ultrasound Med Biol 32(12): 1905-1911, 2006.

10. Fan HB, Hu YY, Zhang C, Li X, Lv R, Qin L, Zhu R. Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold. Biomaterials, 27:4573-4580, 2006.

 

Books

1) 秦嶺(主編):骨內科學 人民衛生出版社) Qin L*. Orthopaedci Medicine (in Chinese. Peoples’ Medical Publishing House (ISBN 978-7-117-18088-7/R·18089; Total 800 pages and 460 figures 2013

2) Leung KS, Qin YX, Cheung WH, Qin L*. A Practical Manual for Musculoskeletal Research. World Scientific 2008

3) Qin L*, Genant HK, Leung KS, Griffith FJ. (eds). Advanced Bioimaging Technologies in Assessment of Quality of Bone and Scaffold Biomaterials. Springer Verlag 2007