Name : WONG, Hei Sunny 黃曦
Title :
Assistant Professor (Clinical)
Home Department :  Medicine and Therapeutics
Email :
Office Phone No. (852) 3505 3137
Website :


Dr Sunny Wong is an Associate Professor at the Department of Medicine and Therapeutics in the Chinese University of Hong Kong. Following his medical qualification at the Chinese University of Hong Kong, he pursued his postgraduate degree to work on human genetics of common infectious diseases at the University of Oxford. He has published over 120 peer-reviewed papers including articles in PLoS Pathogens, Nature Genetics, Gastroenterology and Gut. He has won a number of awards including the National Natural Science Foundation of China (NFSC) Excellent Young Scientists Fund, Hong Kong College of Physicians (HKCP) Distinguished Research Paper Award, and the Croucher Foundation Clinical Academics Development Scheme. His research interests are to understand the host-microbe relationships in various diseases, and to explore novel biomarkers and therapeutics for clinical application.

Specialised Research Area(s):

  • Host-microbiome interaction in human diseases
  • Clostridioides difficile infection
  • Colorectal cancer screening

Selected Publications:

1. Kong KY, Kwong TNY, Chan H, Wong K, Wong SSY, Chaparala AP, Chan RCY, Zhang L, Sung JJY, Yu J, Hawkey PM, Ip M, Wu WKK, Wong SH. Emerging Microbes & Infections. 2020;9(1):631-638.

2. Wong SH, Yu J. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol. 2019;16(11):690-704.

3. Wong SH, Kwong TNY, Wu CY, Yu J. Clinical applications of gut microbiota in cancer biology. Seminars Cancer Biology 2019;55:28-36. 

4. Kwong TNY, Wang X, Nakatsu G, Chow TC, Tipoe T, Dai RZW, Tsoi KKK, Wong MCS, Tse G, Chan MTV, Chan FKL, Ng SC, Wu JCY, Wu WKK, Yu J, Sung JJY, Wong SH. Association between bacteremia from specific microbes and subsequent diagnosis of colorectal cancer. Gastroenterology 2018;155(2):383-90 e8. 

5. Ho J, Dai RZW, Kwong TNY, Wang X, Zhang L, Ip M, Chan R, Hawkey PMK, Lam KLY, Wong MCS, Tse G, Chan MTV, Chan FKL, Yu J, Ng SC, Lee N, Wu JCY, Sung JJY, Wu WKK, Wong SH. Disease burden of clostridium difficile infections in adults, hong kong, china, 2006-2014. Emerging Infectious Diseases 2017;23(10):1671-79.

6. Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J. Gavage of fecal samples from patients with colorectal cancer promotes intestinal carcinogenesis in germ-free and conventional mice. Gastroenterology 2017;153(6):1621-33 e6. 

7. Wong SH, Kwong TNY, Chow TC, Luk AKC, Dai RZW, Nakatsu G, Lam TYT, Zhang L, Wu JCY, Chan FKL, Ng SSM, Wong MCS, Ng SC, Wu WKK, Yu J, Sung JJY. Quantitation of faecal fusobacterium improves faecal immunochemical test in detecting advanced colorectal neoplasia. Gut 2017;66(8):1441-48.

8. Wong SH, Hill AV, Vannberg FO. Genomewide association study of leprosy. New England Journal of Medicine 2010;362(15):1446-7; author reply 1447-8.

9. Wong SH, Gochhait S, Malhotra D, Pettersson FH, Teo YY, Khor CC, Rautanen A, Chapman SJ, Mills TC, Srivastava A, Rudko A, Freidin MB, Puzyrev VP, Ali S, Aggarwal S, Chopra R, Reddy BS, Garg VK, Roy S, Meisner S, Hazra SK, Saha B, Floyd S, Keating BJ, Kim C, Fairfax BP, Knight JC, Hill PC, Adegbola RA, Hakonarson H, Fine PE, Pitchappan RM, Bamezai RN, Hill AV, Vannberg FO. Leprosy and the adaptation of human toll-like receptor 1. PLoS Pathogens. 2010 Jul 1;6:e1000979.

10. Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A; African TB Genetics Consortium; Wellcome Trust Case Control Consortium, Morris AP, Meyer CG, Horstmann RD, Hill AVS. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature Genetics 2010;42(9):739-741.