Research
JIANG Peiyong
Name : JIANG Peiyong 江培勇
Title : Assistant Professor 
Home Department :  Chemical Pathology
Email : jiangpeiyong@cuhk.edu.hk
Phone Number :  (852) 3763 6056 
Address : Rm 503B, Li Ka Shing Medical Sciences Building, The Chinese University of Hong Kong, 
Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China


Biography:

Peiyong Jiang is currently an assistant professor and a bioinformatician at the Department of Chemical Pathology, The Chinese University of Hong Kong. He received his bachelor’s degree in bioengineering from Huzhou Teachers College in 2006. During that time, he was trained in biology, biochemistry, genetics, biostatistics and programming languages. Afterwards, he received his master’s degree of crop genetics and breeding from Huazhong Agricultural University in 2009. During the time of pursuing master’s degree, he was mainly trained in advanced genetics, statistics and bioinformatics. His research work involved the plant microRNA prediction in silico, particularly using machine learning algorithm to explore Next Generation Sequencing (NGS) data. Thereafter, he received his Ph.D. in Chemical Pathology from The Chinese University of Hong Kong in 2012 and had postdoctoral training at the Department of Chemical Pathology, The Chinese University of Hong Kong from 2012 to 2015. Since he joined the department, he has been working on bioinformatics. With a multidisciplinary background of genomics, bioinformatics, computational biology and statistics, he has a long-standing research interest in NGS-based bioinformatics data analysis as well as its applications in clinical development and use.

Specialised Research Area(s):

(1) Developing mathematical algorithms and bioinformatics software for the Next Generation Sequencing (NGS) data analysis.

(2) Developing bioinformatics algorithms for the noninvasive prenatal diagnosis and noninvasive cancer diagnosis.

(3) Field-Programmable Gate Array (FPGA) based computing acceleration for NGS-based big data analysis.

Selected Publications:

1. Jiang PY*, Chan CWM*, Chan KCA*, Cheng SH, Wong J, Wong VWS, Wong GLH, Chan SL, Mok TSK, Chan HLY, Lai PBS, Chiu RWK, Lo YMD. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proceedings of the National Academy of Sciences of the United States of America 2015;112:E1317-E1325. (*contributed equally to this work)

2. Sun K*, Jiang PY*, Chan KCA*, Wong J, Cheng YKY, Liang RHS, Chan W-k, Ma ESK, Chan SL, Cheng SH, Chan RWY, Tong YK, Ng SSM, Wong RSM, Hui DSC, Leung TN, Leung TY, Lai PBS, Chiu RWK, Lo YMD. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proceedings of the National Academy of Sciences 2015;112:E5503-E5512. (*contributed equally to this work)

3. Jiang PY, Sun K, Lun FMF, Guo AM, Wang HT, Chan KCA, Chiu RWK, Lo YMD, Sun H. Methy-pipe: An integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis. Plos One 2014;9.

4. Chan KCA*, Jiang PY*, Chan CWM*, Sun K, Wong J, Hui EP, Chan SL, Chan WC, Hui DSC, Ng SSM, Chan HLY, Wong CSC, Ma BBY, Chan ATC, Lai PBS, Sun H, Chiu RWK, Lo YMD. Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proceedings of the National Academy of Sciences of the United States of America 2013;110:18761-18768. (*contributed equally to this work)

5. Jiang PY, Chan KCA, Liao GJW, Zheng YWL, Leung TY, Chiu RWK, Lo YMD, Sun H. Fetalquant: Deducing fractional fetal DNA concentration from massively parallel sequencing of DNA in maternal plasma. Bioinformatics 2012;28:2883-2890.

6. Chan KCA, Jiang PY, Zheng YWL, Liao GJW, Sun H, Wong J, Siu SSN, Chan WC, Chan SL, Chan ATC, Lai PBS, Chiu RWK, Lo YMD. Cancer genome scanning in plasma: Detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clinical Chemistry 2013;59:211-224.

7. Yu SCY*, Chan KCA*, Zheng YWL*, Jiang PY, Liao GJW, Sun H, Akolekar R, Leung TY, Go ATJI, van Vugt JMG, Minekawa R, Oudejans CBM, Nicolaides KH, Chiu RWK, Lo YMD. Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing. Proceedings of the National Academy of Sciences of the United States of America 2014;111:8583-8588. (*contributed equally to this work)

8. Chan RWY, Jiang PY, Peng X, Tam LS, Liao GJW, Li EKM, Wong PCH, Sun H, Chan KCA, Chiu RWK, Lo YMD. Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing. Proceedings of the National Academy of Sciences of the United States of America 2014;111:E5302-E5311.

9. New MI, Tong YK*, Yuen T*, Jiang PY, Pina C, Chan KCA, Khattab A, Liao GJW, Yau M, Kim SM, Chiu RWK, Sun L, Zaidi M, Lo YMD. Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma. Journal of Clinical Endocrinology & Metabolism 2014;99:E1022-E1030. (*contributed equally to this work)

10. Tsui NBY, Jiang PY, Wong YF, Leung TY, Chan KCA, Chiu RWK, Sun H, Lo YMD. Maternal plasma rna sequencing for genome-wide transcriptomic profiling and identification of pregnancy-associated transcripts. Clinical Chemistry 2014;60:954-962.