LEE, Pui Wai Alex

Name : LEE, Pui Wai Alex  李沛威
Title :

Professor of Medicine and Therapeutics

Home Department :  Medicine and Therapeutics
Email :



Professor Lee specialises in cardiac imaging with particular interest in echocardiography. His main research interests are heart valve disease, heart failure, advanced techniques in echocardiography and the application of cardiac imaging in guiding valvular surgery and structural heart intervention. In patients with dilated cardiomyopathy undergoing mitral valve repair, he established the importance of distal anterior leaflet tethering in the mechanism of recurrence of functional mitral regurgitation. The results of his work have been adopted by guidelines from the European Society of Cardiology, American Association for Thoracic Surgery, and American Society of Echocardiography. More recently, Prof. Lee and his group discovered the mechanistic link of mitral annular saddle shape with annular disjunction and progression of degenerative mitral regurgitation using 3D echocardiography. 

Professor Lee has published over 200 articles in peer-reviewed journals including Circulation, European Heart Journal, Journal of American College of Cardiology, and Journal of American Society of Echocardiography. He has received important research awards including the ESC Young Investigator Award (2008), the Hong Kong College of Physicians Distinguished Research Awards for 3 times (2009, 2011, 2013), the State Ministry of Education First-Class Award in Technology Advancement (2012), the CUHK Research Excellence Award (2014), the Richard Yu Lectureship (2015), and the Distinguished Young Fellows of Hong Kong College of Physicians (2016).

Specialised Research Area(s):

  • Cardiovascular medicine
  • Echocardiography

Selected Publications:

1. Tang Z, Fan YT, Wang Y, Jin CN, Kwok KW, Lee APW. Mitral Annular and Left Ventricular Dynamics in Atrial Functional Mitral Regurgitation: A Three-Dimensional and Speckle-Tracking Echocardiographic Study. Journal of the American Society of Echocardiography. 2019;32(4):503-513. doi:10.1016/j.echo.2018.11.009.

2. Fan Y, Yang F, Cheung GSH, Chan AKY, Wang DD, Lam YY, Chow MCK, Leong MCW, Kam KKH, So KCY, Tse G, Qiao Z, He B, Kwok KW, Lee APW. Device Sizing Guided by Echocardiography-Based Three-Dimensional Printing Is Associated with Superior Outcome after Percutaneous Left Atrial Appendage Occlusion. Journal of the American Society of Echocardiography. 2019;32(6):708-719.e1. doi:10.1016/j.echo.2019.02.003.

3. Lee APW, Jin CN, Fan Y, Wong RHL, Underwood MJ, Wan S. Functional Implication of Mitral Annular Disjunction in Mitral Valve Prolapse. JACC: Cardiovascular Imaging. 2017;10(12):1424-1433. doi:10.1016/j.jcmg.2016.11.022.

4. Fan Y, Kwok KW, Zhang Y, Cheung GSH, Chan AKY, Lee APW. Three-Dimensional Printing for Planning Occlusion Procedure for a Double-Lobed Left Atrial Appendage. Circulation: Cardiovascular Interventions. 2016;9(3). doi:10.1161/circinterventions.116.003561.

5. So KCY, Fan Y, Sze L, Kwok K, Chan AK, Cheung GSH, Lee APW. Using Multimaterial 3-Dimensional Printing for Personalized Planning of Complex Structural Heart Disease Intervention. JACC: Cardiovascular Interventions. 2017;10(11):e97-e98. doi:10.1016/j.jcin.2017.02.045.

Lee APW, Hsiung MC, Salgo IS, Fang F, Xie JM, Zhang YC, Lin QS, Looi JL, Wan S, Wong RHL, Underwood MJ, Sun JP, Yin WH, Wei J, Tsai SK, Yu CM. Quantitative Analysis of Mitral Valve Morphology in Mitral Valve Prolapse With Real-Time 3-Dimensional Echocardiography. Circulation. 2013;127(7):832-841. doi:10.1161/circulationaha.112.118083.

Lee APW, Zhang Q, Yip G, Fang F, Liang YJ, Xie JM, Lam YY, Yu CM. LV Mechanical Dyssynchrony in Heart Failure With Preserved Ejection Fraction Complicating Acute Coronary Syndrome. JACC: Cardiovascular Imaging. 2011;4(4):348-357. doi:10.1016/j.jcmg.2011.01.011.

Lee APW, Lam YY, Yip GWK, Lang RM, Zhang Q, Yu CM. Role of Real Time three-dimensional Transesophageal Echocardiography in Guidance of Interventional Procedures in Cardiology. Heart. 2010;96(18):1485-1493. doi:10.1136/hrt.2009.190025.

Lee APW, Acker M, Kubo SH, Bolling SF, Park SW, Bruce CJ, Oh JK. Mechanisms of Recurrent Functional Mitral Regurgitation after Mitral Valve Repair in Nonischemic Dilated Cardiomyopathy. Circulation. 2009;119(19):2606-2614. doi:10.1161/circulationaha.108.796151.

Lee APW, Song JK, Yip GWK, Zhang Q, Zhu TG, Li C, Chan A, Yu CM. Importance of Dynamic Dyssynchrony in the Occurrence of Hypertensive Heart Failure with Normal Ejection Fraction. European Heart Journal. 2010;31(21):2642-2649. doi:10.1093/eurheartj/ehq248.