Research
Lo Kwok Wai
Name : LO Kwok Wai 羅國煒
Title :
Professor
Home Department :  Anatomical and Cellular Pathology
Email : kwlo@cuhk.edu.hk
Phone Number: (852) 3505 2178
Fax Number: (852) 2637 6274
Address: Room 34135, Clinical Sciences Building, Prince of Wales Hospital, Shatin, N.T.
Website :
http://www.cuhk.edu.hk/med/acp/acp/staff/kwlo.html

Biography:

Academic Positions:
-  Professor, Department of Anatomical & Cellular Pathology, CUHK.
-  Associate Member, School of Biomedical Science, CUHK.
- Investigator, State Key Laboratory in Oncology in South China, CUHK.
Qualification: Ph.D. (CUHK); M.Phil (CUHK); BSc. (CUHK); Fellow of Royal College of Pathologists, U.K. (FRCPath); Associate of Institute of BioMedical Science, U.K. (AIBMS).

Specialised Research Area(s):

Molecular genetics of nasopharyngeal carcinoma (NPC); NPC genomics; Roles of EBV in NPC tumorigenesis; New therapeutic approaches for NPC; Tumor microenvironment and cancer stem-like cells in NPC

Selected Publications:

1. Chung, G. T., Lung, R. W., Hui, A. B., Yip, K. Y., Woo, J. K., Chow, C., Tong, C. Y., Lee, S. D., Yuen, J. W., Lun, S. W., Tso, K. K., Wong, N., Tsao, S. W., Yip, T. T., Busson, P., Kim, H., Seo, J. S., O'Sullivan, B., Liu, F. F., To, K. F., & Lo, K.W. (2013). Identification of a recurrent transforming UBR5-ZNF423 fusion gene in EBV-associated nasopharyngeal carcinoma. The Journal of Pathology, 231(2),158-167.

2. Chung, G. T., Lou, W. P., Chow, C., To, K. F., Choy, K. W., Leung, A. W., Tong, C. Y., Yuen, J. W., Ko, C. W., Yip, T. T., Busson, P., & Lo, K. W. (2013). Constitutive activation of distinct NF-κB signals in EBV-associated nasopharyngeal carcinoma. The Journal of Pathology, 231(3), 311-322.

3. Lo, K. W., Chung, G. T., & To, K. F. (2012). Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches.Seminars in Cancer Biology, 22(2), 79-86.

4. Chow, C., Wong, N., Pagano, M., Lun, S. W., Nakayama, K. I., Nakayama, K., & Lo, K. W. (2012). Regulation of APC/CCdc20 activity by RASSF1A-APC/CCdc20 circuitry. Oncogene, 31(15), 1975-1987.

5. Man, C. H., Lun, S. W., Hui, J. W., To, K. F., Choy, K. W., Chan, A. W., Chow, C., Chung, G. T., Tsao, S. W., Yip, T. T., Busson, P., & Lo, K. W. (2012). Inhibition of NOTCH3 signaling significantly enhances sensitivity to cisplatin in EBV-associated nasopharyngeal carcinoma. The Journal of Pathology, 226(3), 471-481.

6. Or, Y. Y., Chung, G. T., To, K. F., Chow, C., Choy, K. W., Tong, C. Y., Leung, A. W., Hui, A. B., Tsao, S. W., Ng, H. K., Yip, T. T., Busson, .P, & Lo, K. W. (2010). Identification of a novel 12p13.3 amplicon in nasopharyngeal carcinoma. The Journal of Pathology, 220(1), 97-107.

7. Hui, A. B., Or, Y. Y., Takano, H., Tsang, R. K., To, K. F., Guan, X. Y., Sham, J. S., Hung, K. W., Lam, C. N., van Hasselt, C. A., Kuo, W. L., Gray, J. W., Huang, D. P., & Lo, K. W. (2005). Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma. Cancer Research, 65(18), 8125-8133.

8. Lo, K. W., To, K. F., & Huang, D. P. (2004). Focus on nasopharyngeal carcinoma. Cancer Cell, 5(5), 423-428.