Research
Name : LUI Oi Lan, Kathy 呂愛蘭
Title : Assistant Professor
Home Department:  Chemical Pathology
Email : kathyolui@cuhk.edu.hk
Phone Number: (852) 3763 6034
Website : http://www.cpy.cuhk.edu.hk/Research/KathyLui.htm
http://www.cuhk.edu.hk/research/luilab

Biography:

Dr. Kathy Lui received her Bachelor of Science and Master of Philosophy degrees from the Department of Biochemistry, The Chinese University of Hong Kong. With support from the full scholarship, Dorothy Hodgkin Postgraduate Award, Dr. Lui completed her Ph.D in the field of Stem Cell Immunology at Sir William Dunn School of Pathology, University of Oxford, U.K. Dr. Lui was also the recipient of Senior Scholarship at Lincoln College, Oxford, U.K. and Peter Beaconsfield Prize in Physiological Sciences, Oxford, U.K. which is awarded specifically to young researchers who are ‘capable of escaping from the stereotype of narrow specialization, and who display a wider grasp of the significance and potential applicability of their research’. Thereafter, Dr. Lui received the Croucher Foundation Fellowship and continued her postdoctoral training in the field of Stem Cells and Vascular Regeneration at Massachusetts General Hospital and Department of Stem Cell and Regenerative Biology, Harvard University, U.S. Dr. Lui has granted two patents during her postdoctoral training in the U.S.

Specialised Research Area(s):

The following highlights her current research efforts:

• Vascular regeneration

• Identification of novel angiocrine factors involved in regeneration

• Immunogenecity of human pluripotent stem cell-derived vascularized tissues

• Transplantation of human pluripotent stem cell-derived vascularized tissues

 

Selected Publications: 

1. Hui Z, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Zeng H, Lui K, Zhou B. Cardiac fat derived from the endocardium. Circulation Research 2016; 118 (2): 254-265. 

2. Liu QZ, Yang R, Huang XZ, Zhang H, He LJ, Zhang LB, Tian XY, Nie Y, Hu SS, Yan Y, Zhang L, Qiao ZY, Wang QD, Lui KO, Zhou B. Genetic lineage tracing identifies in situ kit-expressing cardiomyocytes. Cell Research 2016; 26: 119-130.

3. Chetty S, Engquist E, Mehanna E, Lui KO, Tsankov A, Melton D. A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation. The Journal of Cell Biology 2015; 210(7): 1257-1268.

4. Chien KR, Zangi L, Lui KO. Synthetic chemically modified mrna (modrna): Toward a new technology platform for cardiovascular biology and medicine. Cold Spring Harbor Perspectives in Medicine 2015; 5: a014035.

5. Lui KO*, Howie D, Ng SW, Liu SB, Chien KR, Waldmann H*. Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nature Communications 2014; 5. *Correspondence

6. Sahara M, Hansson EM, Wernet O, Lui KO, Spater D, Chien KR. Manipulation of a vegf-notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells. Cell Research 2014; 24: 820-841.

7. Zangi L#, Lui KO#, von Gise A, Ma Q, Ebina W, Ptaszek LM, Spater D, Xu HS, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. Modified mrna directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nature Biotechnology 2013; 31: 898-+. #Equal contribution

8. Lui KO*, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR*. Driving vascular endothelial cell fate of human multipotent isl1(+) heart progenitors with vegf modified mrna. Cell Research 2013; 23: 1172-1186. *Correspondence

9. Xu HS, Yi BA, Wu H, Bock C, Gu HC, Lui KO, Park JHC, Shao Y, Riley AK, Domian IJ, Hu E, Willette R, Lepore J, Meissner A, Wang Z, Chien KR. Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Research 2012; 22: 142-154.

10. Lui KO, Boyd AS, Cobbold SP, Waldmann H, Fairchild PJ. A role for regulatory t cells in acceptance of esc-derived tissues transplanted across an major histocompatibility complex barrier. Stem Cells 2010; 28: 1905-1914.

11. Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, Fairchild PJ, Mellor AL, Ron D, Waldmann H. Infectious tolerance via the consumption of essential amino acids and mtor signaling. Proceedings of the National Academy of Sciences of the United States of America 2009; 106: 12055-12060.