Research
TANG Leung Sang Nelson
Name : TANG Leung Sang Nelson 鄧亮生
Title : Professor
Home Department :  Chemical Pathology
Email : nelsontang@cuhk.edu.hk
Website : www.cpy.cuhk.edu.hk/Research/NelsonTang.htm

Biography:

https://publons.com/researcher/2047982/nelson-l-tang/

2002                Doctor of Medicine (CUHK) 
2002 Fellow of the Hong Kong Society of Clinical Chemistry
1998 Accredited Clinical Biochemists (Hong Kong)
1997  FRCPA, Fellow of the Royal College of Pathologists of Australasia (FRCPA)
1991 MBChB, Bachelor of Medicine and Bachelor of Surgery, MB ChB (CUHK)

Adjunct and honorary positions:

2014 -   Course coordinator of BMEG 5790 Bioinformatics in MSc porgram in Biomedical Engineering 
2014 -  Member of Preclinical Education Committee
2013 -  Member, Grant Review Board of Health and Medical Research Fund, Hong Kong SAR Government
2013 - Primary Supervisor of training in Genetic Pathology for Royal College of Pathologists of Australasia (RCPA) at Prince of Wales Hospital
2013 -  Member, Editorial Board of the journal Pathology
2009 - 2014    Scientific Editor, Catalogue of Genetic Tests and Laboratories, Royal College of Pathologists of Australasia
2009, 2013 Committee member, Manual Transformation Steering Committee, Royal College of Pathologists of Australasia
2009 -  Member, The Committee of Board Directors for Asian Society of Inherited Metabolic Diseases (ASIMD)
2009 -  Associate Director, KIZ / CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases
2007 - now Principal Investigator, Laboratory for Genetics of Disease Susceptibility, Li Ka Shing Institute of Health Sciences, CUHK
2005 - 2012 Member, Advisory Committee of Genetics Pathology in the Royal College of Pathologists of Australasia (RCPA)
2005 - 2010 Panel Coordinator of teaching panel in medical curriculum: Mechanisms of Disease and Therapeutic Approaches
2007 Honorary Professor, Xi'an Jiaotong University, Xi'an China
2006  Overseas Examiner of Genetics Pathology for the Royal College of Pathologists of Australasia (RCPA)

Specialised Research Area(s):

Human Genetics, Population Genetics, Statistical Genetics

Selected Publications: 

1.  Tang, N. L. S., & Hui, J. (2020). 20 Years After Discovery of the Causative Gene of Primary Carnitine Deficiency, How Much More Have We Known About the Disease? HK J Paediatr (new series), 25:23-29.  http://www.hkjpaed.org/details.asp?id=1267&show=1234.

2.  Styrkarsdottir, U., Stefansson, O. A., Gunnarsdottir, K., et al. (2019). GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures. Nature Communications, 10(1), 2054. https://doi.org/10.1038/s41467-019-09860-0.

3.  Styrkarsdottir, U., Helgason, H., Sigurdsson, A., et al. (2017). Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nature Genetics, 49(5), 801–805. https://doi.org/10.1038/ng.3816.

4. Styrkarsdottir, U., Thorleifsson, G., Gudjonsson, S. A., et al. (2016). Sequence variants in the PTCH1 gene associate with spine bone mineral density and osteoporotic fractures. Nature Communications, 7, 10129. https://doi.org/10.1038/ncomms10129.

5. Zhu, Z., Tang, N. L.-S., Xu, L., et al. (2015). Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls. Nature Communications, 6, 8355. https://doi.org/10.1038/ncomms9355.

6. Estrada, K., Styrkarsdottir, U., Evangelou, E., et al. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491–501. https://doi.org/10.1038/ng.2249.

7. Wan, X., Yang, C., Yang, Q., Xue, H., Fan, X., Tang, N. L. S., & Yu, W. (2010). BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies. American Journal of Human Genetics, 87(3), 325–340. https://doi.org/10.1016/j.ajhg.2010.07.021.

8. Khor, C. C., Vannberg, F. O., Chapman, S. J., et al. (2010). CISH and susceptibility to infectious diseases. The New England Journal of Medicine, 362(22), 2092–2101. https://doi.org/10.1056/NEJMoa0905606.

9. Woo, J., Tang, N., Suen, E., Leung, J., & Wong, M. (2009). Green space, psychological restoration, and telomere length. Lancet (London, England), 373(9660), 299–300. https://doi.org/10.1016/S0140-6736(09)60094-5.

10. Tang, N. L.-S., Chan, P. K.-S., Hui, D. S.-C., To, K.-F., Zhang, W., Chan, F. K. L., Sung, J. J.-Y., & Lo, Y. M. D. (2007). Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection. Nature Genetics, 39(6), 691–692. https://doi.org/10.1038/ng0607-691.