Research
TANG Leung Sang Nelson
Name : TANG Leung Sang Nelson 鄧亮生
Title : Professor
Home Department :  Chemical Pathology
Email : nelsontang@cuhk.edu.hk
Website : http://www.cpy.cuhk.edu.hk/Research/NelsonTang.htm

Biography:

2002 Doctor of Medicine (CUHK)
2002 Fellow of the Hong Kong Society of Clinical Chemistry
1998 Accredited Clinical Biochemists (Hong Kong)
1997 FRCPA, Fellow of the Royal College of Pathologists of Australasia (FRCPA)
1991 MBChB, Bachelor of Medicine and Bachelor of Surgery, MB ChB (CUHK)

Adjunct and honorary positions:

2009 – now Associate Director, KIZ / CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases
Professional Committees and other Academic Activities
2005- 2012   Advisory Committee of Genetics Pathology in the Royal College of Pathologists of Australasia
2006 Overseas Examiner of Genetics Pathology for the Royal College of Pathologists of Australasia
2006 Co-Director, Croucher Foundation Advance Study Institute on Genetic Statistics (Co-Directors: Pak Sham and Nelson Tang)
2009 - Scientific Editor, Catalogue of Genetic Tests and Laboratories, Royal College of Pathologists of Australasia
2009 - 2013 Committee member, Manual Transformation Steering Committee, Royal College of Pathologists of Australasia
2012- Advisor, Human Variome Project- China node


Specialised Research Area(s):

Human Genetics, Population Genetics, Statistical Genetics

Selected Publications: 

1.  Buchan, J. G., Alvarado, D. M., Haller, G. E., Cruchaga, C., Harms, M. B., Zhang, T., Willing, M. C., Grange, D.K., Braverman, A. C., Miller, N. H., Morcuende, J. A., Tang, N. L., Lam, T. P., Ng, B. K., Cheng, J. C., Dobbs, M. B., & Gurnett, C. A. (2014). Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis. Human Molecular Genetics. . [Epub ahead of print]

2.  Chen, H. Y., Huang, W., Leung, V. H., Fung, S. L., Ma, S. L., Jiang, H., & Tang, N. L. (2013). Functional interaction between SNPs and microsatellite in the transcriptional regulation of insulin-like growth factor 1. Human Mutation, 34(9),1289-1297.

3.  Ji, L. D., Qiu, Y. Q., Xu, J., Irwin, D. M., Tam, S. C., Tang, N. L., & Zhang, Y. P. (2012). Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations. Molecular Biology and Evolution, 29(11), 3359-3370.

4. Estrada, K., Styrkarsdottir, U., Evangelou, E., Hsu, Y. H., Duncan, E. L., Ntzani, E. E., Oei, L., Albagha, O. M., Amin, N., Kemp, J. P., Koller, D. L., Li, G., Liu, C. T., Minster, R. L., Moayyeri, A., Vandenput, L., Willner, D., Xiao, S. M., Yerges-Armstrong, L. M., Zheng, H. F., Alonso, N., Eriksson, J., Kammerer, C. M., Kaptoge, S. K., Leo, P. J., Thorleifsson, G., …, Tang, N. L.., …, Ioannidis, J. P., Kiel, D. P. & Rivadeneira, F. (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491-501.

5. Wan, X., Yang, C., Yang, Q., Xue, H., Fan, X., Tang, N. L., & Yu, W. (2010). BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies. The American Journal of Human Genetics, 87(3), 325-340.

6. Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D.,Rautanen, A., Mills, T. C., Chang, K. C., Kam, K. M., Crampin, A. C., Ngwira, B., Leung, C. C., Tam, C. M., Chan, C. Y., Sung, J. J., Yew, W. W., Toh, K. Y., Tay, S. K., Kwiatkowski, D., Lienhardt, C., Hien, T. T., Day, N. P., Peshu, N., Marsh, K., Maitland, K., Scott, J. A., Williams, T. N., Berkley, J. A., Floyd, S., Tang, N. L., Fine, P. E., Goh, D. L., & Hill, A. V. (2010). CISH and susceptibility to infectious diseases. The New England Journal of Medicine, 362(22), 2092-2101.

7. Thorleifsson, G., Walters, G. B., Hewitt, A. W.,... Tang, N. L...., et al. (2010). Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nature Genetics, 42(10), 906-909.

8. Woo, J., Tang, N. L., Suen, E.,Leung, J., & Wong, M. (2009). Green space, psychological restoration and telomere length. Lancet, 373(9660), 299-300.

9. Tang, N. L., Chan, P. K., Hui, D. S., To, K. F., Zhang, W., Chan, F. K., Sung, J. J., & Lo, Y. M. (2007). Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection. Nature Genetics, 39(6), 691-692.

10. Tang, N. L., Ganapathy, V., Wu, X., Hui, J., Seth, P., Yuen, P. M., Wanders, R. J., Fok, T. F., & Hjelm, N. M. (1999). Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency. Human Molecular Genetics, 8(4), 655-660.