Research
WANG, Yao Max

Name : WANG, Yao Max 王堯
Title :

Research Assistant Professor
Home Department :  Obstetrics and Gynaecology
Email : yaowang1@cuhk.edu.hk
Phone Number: 
 (852) 3505 1289
Website:  https://www.obg.cuhk.edu.hk/about-us/our-staff/prof-wang-yao-max/


 

Biography:

Dr. Wang is a distinguished Research Assistant Professor with a robust academic background and a keen focus on ground-breaking research in maternal-fetal health. He earned his Bachelor of Science from Sun Yat-sen University and achieved his Ph.D. degree at the University of Hong Kong. Following three years of post-doctoral training in the Department of Medicine at the University of Hong Kong, Dr. Wang brings high expertise in metabolism and endocrinology to Obstetrics & Gynaecology. Dr. Wang's research transcends traditional boundaries, integrating metabolic and endocrine dimensions into the study of gestational health. This integrative approach not only enriches his biomarker research but also provides a holistic view of the interplay of hormonal and microbiome on gestational diseases. His contributions epitomize the synergy of interdisciplinary research in advancing the frontiers of maternal-fetal medicine. In addition, Dr. Wang intends to translate research insights into practical strategies for clinical implantation. He aims to apply lifestyle intervention (e.g., physical exercise and healthy diet) to enhance prenatal and postnatal care and optimize pregnancy outcomes.

 

Specialised Research Area(s):

  • Biomarker Discovery: Dedicated to uncovering new biomarkers to enhance the predictive accuracy and diagnostic capabilities for gestational diseases
  • Reproductive and Maternal-fetal Metabolism: Focused on elucidating the influence of hormones and cytokines on pregnancy progression and outcomes
  • Gestational Microbiome: Investigating the impact of gut and vaginal microbiota on the emergence of gestational disorders
  • Lifestyle Interventions: Implementing dietary and physical activity strategies to bolster the well-being of mothers and offspring
  • Therapeutical responsiveness: To investigate the therapy responsiveness for preeclampsia treatment and prevention

Selected Publications:

1. Y. Yang*, J. Wu*, X. Wang*, J. Yao, K. S. Lao, Y. Qiao, Y. Xu, Y. Hu, Y. Feng, Y. Cui, S. Shi, J. Zhang, M. Liang, Y. Pan, K. Xie, K. Yan, Q Li#, D. Ye#, Y. Wang#. Circulating fibroblast growth factor 21 as a potential biomarker for missed abortion in humans. Fertility & Sterility. 116.4 (2021): 1040-1049. (IF=6.7; Q1, 4/197 Obstetrics and Gynecology)

2. Q. Li, C. Wu, J. Wu, L. C. Poon, C. Wang, X. Guo, L. Song, X. Wang, Q. Zhang, Z. Ye, Y. Yang, J. Lu, T. Zhang, D. Ye*, Y. Wang*. Serum soluble PD-L1 level is decreased in early fetal loss and associated with placental dysfunction. Human Reproduction. 10.1093/humrep/dead178 (IF=6.1; Q1, 3/197 Obstetrics and Gynecology) 

3. B. K. Alemu, G. G. Azeze, L. Wu, C. C. Wang, Y. Wang*, Effects of maternal probiotic supplementation on breast milk microbiome and infant gut microbiome and health: a systematic review and meta-analysis of randomized controlled trials. American Journal of Obstetrics & Gynecology Maternal-Fetal Medicine (AJOG FMF) 10.1016/j.ajogmf.2023.101148, (IF=6.3; Q1, 15/197 Obstetrics and Gynecology)

4. Y. Liu*, Y. Wang*, Y. Ni*, C. K.Y Chong, K. S.L. Lam, Y. Wang, Z. Xia, D. Ye, J. Guo, M. A. Tse#, G. Panagiotou#, A. Xu#. Gut microbiome fermentation determines the therapeutic efficacy of exercise for diabetes prevention. Cell Metabolism. (2020) 31, 1-15. Co-First author (IF=31.4; Q1, 6/376, Molecular biology)

5. C. D. Canestro, J. Chen, Y. Liu, Y. Wang, C. H. Lee, K. S. L. Lam, M. A. Tse, A. Xu. A machine learning algorithm integrating baseline proteomic signatures predicts exercise responsiveness in overweight individuals with prediabetes. Cell Reports Medicine. 100944 (2023) (IF=17.0; Q1, 40/204, Biochemistry, Genetics and Molecular Biology)

6. S. W. Hung, M. Gaetani, Y. Li , Z. Tan, G. C. W. Man, Xu Z., R. Zhang, Y. Ding, T. Zhang, Y. Song, Y. Wang, J. P. W. Chung, T. H. Chan, R. A. Zubarev, C. C. Wang, Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis, Journal of Pharmaceutical Analysis (IF=8.8, Q1, 16/277, Pharmacology & Pharmacy)

7. L. Jin, L. Geng, L. Ying, L. Shu, K. Ye, R. Yang, Y. Liu, Y. Wang, Y. Cai, X. Jiang, Q. Wang, X. Yan. B. Liao, J. Liu, F. Duan, G. Sweeney, C. Woo, Y. Wang, Z. Xia, Q. Lian, A. Xu. The FGF21-Sirtui 3 axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity, Circulation. (2022):101161CIRCULATIONAHA122059631. (IF=39.9; Q1, 1/336, Cardiology and Cardiovascular Medicine)

8. J. H.C. Yiu, K-S Chan, J. Cheung, J. Li, Y. Liu, Y. Wang, W. W.L. Fung, J. Cai, S. W.M. Cheung, B. Dorweiler, E. Y.F. Wan, P. Tso, A. Xu, C. W. Woo, Gut microbiota-associated activation of TLR5 induces apolipoprotein A1 2 production in the liver, Circulation Research. 127.10 (2020): 1236-1252, (IF=23.2; Q1, 2/322, Cardiology and Cardiovascular Medicine)