Research
Wang Huating
Name : WANG Huating 王華婷
Title : Assistant Professor
Home Department:  Obstetrics and Gynaecology
Email : huating.wang@cuhk.edu.hk
Phone Number:
(852) 3763 6047
Fax Number :
(852) 2636 0008
Address: Room 507A, Li Ka Shing Medical Sciences Building, Prince of Wales Hospital, Shatin, N.T., Hong Kong
Website : http://department.obg.cuhk.edu.hk/staff/staffdetails.asp?staff=2EA3A6

Biography:

i) Academic Qualifications:
2004 Ph.D. Ohio State University, USA
1996 B.S. Nanjing University, China

ii) Previous Academic Position:
2004 – 2008 Postdoctoral Fellow, Ohio State University, USA.

iii) Present Academic Position:
2009-present Assistant Professor, Department of Obstetrics & Gynecology, CUHK

iv) Research Interests:

Identification and characterization of long non-coding RNAs in skeletal muscle stem cells and muscle regeneration.
Functional characterization of lncRNAs in human endometrial cancers.

v) Awards
NIH Ruth L. Kirschestein National Research Service Award, USA
OSU Cancer Center Postdoctoral Fellowship, USA
Participation Support Award for Symposium on Antiviral Drug Resistance, USA
OSU Graduate and Postgraduate Research Day Award, USA
Professional Development Fellowship, OSU, USA
Travel Fellowship, MCDB Program, OSU, USA

Specialised Research Area(s):

Non-coding RNAs and gene regulation in skeletal muscle stem cells.

 

Selected Publications: 

1. Sun, K., Zhao, Y., Wang, H., & Sun, H. (2014). Sebnif: An Integrated Bioinformatics Pipeline for the Identification of Novel Large Intergenic Noncoding RNAs (lincRNAs) -Application in Human Skeletal Muscle Cells. PLoS One, 9(1), e84500.

2. Yang, Y., Zhou, L., Lu, L., Wang, L., Li, X., Jiang, P., Chan, L. K., Zhang, T., Yu, J., Kwong, J., Cheung, T. H., Chung, T., Mak, K., Sun, H.*, & Wang, H*. (2013). A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. Oncogene, 32(29), 3432-3442.

3. Sun, K., Chen, X., Jiang, P., Song, X., Wang, H., & Sun, H. (2013). iSeeRNA: identification of long intergenic non-coding RNA transcripts from transcriptome sequencing data, BMC Genomics, 14 Suppl 2, S7.

4. Guo, A. M., Sun, K., Su, X., Wang, H., & Sun, H. (2013). YY1TargetDB: an integral information resource for Yin Yang 1 target loci, Database (Oxford), bat007.

5. Lu, L., Sun, K., Chen, X., Zhao, Y., Wang, L., Zhou, L., Sun, H.*, & Wang, H.* (2013). Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis, EMBO Journal, 32(19), 2575-2588.

6. Diao, Y., Guo, X., Li, Y., Sun, K., Lu, L., Jiang, L., Fu, X., Zhu, H., Sun, H., Wang, H., & Wu, Z. (2012). Pax3/7BP, is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. Cell Stem Cell, 11(2), 231-241.

7. Song, X., Wang, M., Chen, Y. P., Wang, H., Han, P., & Sun, H. (2013). Prediction of pre-miRNA with multiple stem-loops using pruning algorithm. Computers in Biology and Medicine, 43(5), 409-416. 

8. Wang, S., Cheng, Y., Du, W., Lu, L., Zhou, L., Wang, H., Kang, W., Li, X., Tao, Q., Sung, J. J., & Yu, J. (2013). Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer, Gut, 62(6), 833-841.

9. Zhou, L., Wang, L., Lu, L., Jiang, P., Sun, H., & Wang, H. (2012). A novel target of microRNA-29, Ring1 and YY1 binding protein (Rybp), negatively regulates skeletal myogenesis. Journal of Biological Chemistry, 287(30), 25255-25265.

10. Wang, L., Zhou, L., Jiang, P., Lu, L., Chen, X., Lan, H., Guttridge, D. C., Sun, H., & Wang, H. (2012). Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis. Molecular Therapy, 20(6), 1222-1233.

11. Lu, L., Zhou, L., Chen, E. Z., Sun, K., Jiang, P., Wang, L., Su, X., Sun, H., & Wang, H. (2012). A Novel YY1-miR-1 regulatory circuit in skeletal myogenesis revealed by genome-wide prediction of YY1-miRNA network. PLoOne, 7(2), e27596.

12. Zhou, L., Wang, L., Lu, L., Jiang, P., Sun, H., & Wang, H. (2012). Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts. PLoS One, 7(3), e33766.

13. Acharyya, S., Sharma, S. M., Cheng, A. S., Ladner, K. J., He, W., Kline, W., Wang, H., Ostrowski, M. C., Huang, T. H., & Guttridge, D. C. (2010). TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One, 5(8), e12479. 

14. Raices, R. M., Kannan, Y., Bellamkonda-Athmaram, V., Seshadri, S., Wang, H., Guttridge, D. C., & Wewers, M. D. (2009). A novel role for IkappaBzeta in the regulation of IFNgamma production. PLoS One 4(8), e6776. 

15. Wang, H., Sun, H., & Guttridge, D. C. (2009). microRNAs: novel components in a muscle gene regulatory network. Cell Cycle, 8(12), 1833-1837.