Biography:

i) Academic Qualifications:
2004 Ph.D. Ohio State University, USA
1996 B.S. Nanjing University, China

ii) Previous Academic Position:
2004 – 2008 Postdoctoral Fellow, Ohio State University, USA.

iii) Present Academic Position:
2009-present Assistant Professor, Department of Obstetrics & Gynecology, CUHK

iv) Research Interests:

v) Awards
NIH Ruth L. Kirschestein National Research Service Award, USA
OSU Cancer Center Postdoctoral Fellowship, USA
Participation Support Award for Symposium on Antiviral Drug Resistance, USA
OSU Graduate and Postgraduate Research Day Award, USA
Professional Development Fellowship, OSU, USA
Travel Fellowship, MCDB Program, OSU, USA

Specialised Research Area(s):

Muscle Stem Cell and gene regulation in skeletal muscle stem cells.

1. Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A. Esteban, Hao Sun, Wang H. (2019) MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nature Communications 10, 5787 (2019).

2. Zhou J, So KK, Li Y, Li Y, Yuan J, Ding Y, Chen F, Huang Y, Liu J, Lee W, Li G, Ju Z, Sun H, Wang H. (2019) Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells. Aging Cell 2019 Jul 20:e12996.

3. Chen F, Zhou J, Li Y, Zhao Y, Yuan J, Cao Y, Wang L, Zhang Z, Zhang B, Wang CC, Cheung TH, Wu Z, Wong CC, Sun H, Wang H. (2019) YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells. EMBO Journal. 2019 May 15;38(10).

4. Peng X, So KK, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S, Yao H, Hu P, Sun H, Wang H. (2017) MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Research. 2017 Sep 6;45(15):8785-8805.

5. Zhou J, Zhang S, Wang H, Sun H. (2017) LncFunNet: an integrated computational framework for identification of functional long noncoding RNAs in mouse skeletal muscle cells. Nucleic Acids Research. 2017 Jul 7;45(12):e108.

6. Chen X, He L, Zhao Y, Li Y, Zhang S, Sun K, So K, Chen F, Zhou L, Lu L, Wang L, Zhu X, Bao X, Esteban MA, Nakagawa S, Prasanth KV, Wu Z, Sun H, Wang H. (2017) Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity. Cell Discovery. 2017 Mar 14;3:17002.

7. Zhou, L., Sun, K., Zhao, Y., Zhang, S., Wang, X., Li, Y., Lu, L., Chen, X., Chen, F., Bao, X., Zhu, X., Wang, L., Tang, L. Y., Esteban, M. A., Wang, C. C., Jauch, R., Sun, H. & Wang, H. (2015) Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1. Nature Communications. 6:10026. 

8. Wang, L., Zhao, Y., Bao, X., Zhu, X., Kwok, Y. K., Sun, K., Chen, X., Huang, Y., Jauch, R., Esteban, M. A., Sun, H., & Wang, H. (2015) LncRNA Dum Interacts with Dnmts to Regulate Dppa2 Expression during Myogenic Differentiation and Muscle Regeneration. Cell Research, 5(3):335–350.

9. Zhao, Y., Yang, Y., Trovik, J., Sun, K., Zhou, L., Jiang, P., Lau, T. S., Hoivik, E. A., Salvesen, H. B., Sun, H., & Wang, H. (2014) A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer. Cancer Research, 74(18):5103-17.

10. Lu, L., Sun, K., Chen, X., Zhao, Y., Wang, L., Zhou, L., Sun, H., & Wang, H. (2013) Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis. EMBO Journal, 32(19), 2575-2588.