Research
WU, Ka Kei William
Name : WU, Ka Kei William 胡嘉麒
Title : Assistant Professor (Non-clinical)
Home Department :  Anaesthesia and Intensive Care
Email : wukakei@cuhk.edu.hk
Office Phone Number :
(852) 3505 3147
Office Fax Number :
(852) 2637 2422
Office Address :
 04C14, 4/F, Main Clinical Building and Trauma Centre,
Prince of Wales Hospital, Shatin, N.T., Hong Kong
Website : http://www.cuhk.edu.hk/med/ans/prof_william_wu.htm

Biography:

William KK Wu is an Assistant Professor of the Department of Anaesthesia and Intensive Care. He obtained his PhD in Medical Sciences from CUHK in 2009 and received post-doctoral training in the Institute of Digestive Diseases, CUHK afterwards. As of Oct 2016, he has published more than 150 peer-reviewed articles in international journals, including Gut, Cell Research, Nature Communications, Autophagy, Cancer Research and Oncogene, and 4 book chapters. His research interests include autophagy, cancer biology, sepsis and translational genomics. His research achievements have been recognized both nationally and internationally. He has been awarded the Outstanding Research Postgraduate Student Award by HKU, the Young Researcher Award by CUHK, the First-class Higher Education Outstanding Scientific Research Output Award (Natural Science) by the Ministry of Education of China and FRCPath by the Royal College of Pathologists (London, UK). He also obtained numerous external competitive grants, including 4 Health and Medical Research Fund and 1 RGC-Early Career Scheme, in the capacity of Principal Investigator.

Specialised Research Area(s):

Autophagy; Host defense peptides; Sepsis; Cancer biology and genomics 

Selected Publications:

1.  Wu WKK*, Yu J, Chan MTV, To KF, Cheng ASL* (2016) Combinatorial epigenetic deregulation by Helicobacter pylori and Epstein-Barr virus infections in gastric tumorigenesis. Journal of Pathology 239(3):245-9. (*co-corresponding authors)

2.  Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MHT, Gin T, Chan MTV*, Wu WKK* (2016) Autophagy in sepsis: degradation into exhaustion? Autophagy 12(7):1073-82.  (*co-corresponding authors)

3. Li X, Wu WKK*, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MTV, Lu Y, Sung JJY, Yu J* (2016) Distinct subtypes of gastric cancer defined by molecular characterization Include novel mutational signatures with prognostic capability. Cancer Research 76(7):1724-32. (*co-corresponding authors)

4. Tsang DPF, Wu WKK, Kang W, Lee YY, Wu F, Yu Z, Xiong L, Chan AW, Tong JH, Yang W, Li MSM, Lau SS, Li X, Lee SD, Yang Y, Lai PBS, Yu DY, Xu G, Lo KW, Chan MTV, Wang H, Lee TL, Yu J, Wong N, Yip KY, To KF, Cheng ASL (2016) Yin Yang 1-mediated epigenetic silencing of tumor-suppressive microRNAs contributes to nuclear factor-κB activation in hepatocellular carcinoma. Journal of Pathology 238(5):651-64. (equal contribution)

5. Yu J, Wu WKK, Li X, He J, Li XX, Ng SM, Yu C, Gao Z, Yang J, Li M, Wang Q, Liang Q, Pan Y, Tong JH, To KF, Wong N, Zhang N, Chen J, Lu Y, Lai PBS, Chan FKL, Li Y, Kung HF, Yang H, Wang J, Sung JJY (2015) Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer. Gut 64(4):636-45. (equal contribution)

6. Nakatsu G, Li X, Zhou H, Sheng J, Wong SH, Wu WKK, Ng SC, Tsoi H, Dong Y, Zhang N, He Y, Kang Q, Cao L, Wang K, Zhang J, Liang Q, Yu J, Sung JJY (2015) Gut mucosal microbiome across stages of colorectal carcinogenesis. Nature Communications 6:8727. (equal contribution)

7. Shen J, Xiao Z, Wu WKK*, Wang MH, To KF, Chen Y, Yang W, Li MSM, Shin VY, Tong JH, Zhang L, Li M, Wang L, Lu L, Chan RLY, Wong SH, Yu J, Chan MTV, Chan FKL, Sung JJY, Cheng ASL*, Cho CH (2015) Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Research 75(4):754-65. (equal contribution; *co-corresponding authors)

8. Yu C, Yu J, Yao X, Wu WKK, Lu Y, Li X, Tang S, Li B, Li X, Hou Y, Wu R, Jian M, Wu H, Chen Y, Xu L, Fan F, He J, Liang Q, Wang H, Hu X, He M, Zhang X, Zheng H, Li Q, Yang X, Zhu S, Chen R, Zhang F, Xu X, Yang H, Wang J, Zhang X, Sung JJY, Li Y, Wang J (2014) Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing. Cell Research 24(6):701-12. (equal contribution)

9. Zhang L, Sung JJY, Yu J, Ng SC, Wong SH, Cho CH, Ng SSM, Chan FK*, Wu WKK* (2014) Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer. Journal of Pathology 233(2):103-112. (*co-corresponding authors)

10. Wong XJ, Yu J*, Wong, SH, Cheng ASL, Chan FKL, Ng SSM, Cho CH, Sung JJY*, Wu WKK* (2013) A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy. Autophagy 9(10):1500-08. (*co-corresponding authors)

11. Wong SH, Sung JJY*, Chan FKL, To KF, Ng SSM, Wang XJ, Yu J*, Wu WKK* (2013) Genome-wide association and sequencing studies on colorectal cancer. Seminars in Cancer Biology 23(6 Pt B):502-511. (*co-corresponding authors)

12. Ren SX, Cheng ASL, To KF, Tong JHM, Li MS, Shen J, Wong CCM, Zhang L, Chan RLY, Wang XJ, Ng SSM, Chiu LCM, Marquez VE, Gallo RL, Chan FKL, Yu J, Sung JJY, Wu WKK*, Cho CH (2012) Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Research 72(24):6512-23. (*corresponding author)

13. Wu WKK*, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FKL, Yu J*, Sung JJY* (2012) The autophagic paradox in cancer therapy. Oncogene 31(8):939-53. (*co-corresponding authors)

14. Wu WKK*, Cho CH*, Wu YC, Yu L, Li ZJ, Lee CW, Wong CCM, Li HT, Zhang L, Ren SX, Che CT, Wu K, Fan D, Yu J, Sung JJY* (2010) Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy 6(2):228-238. (*co-corresponding authors)

15. Wu WKK, Lee CW, Cho CH, Fan D, Wu K, Yu J, Sung JJY (2010) MicroRNA dysregulation in gastric cancer: A new player enters the game. Oncogene 29(43):5761-71.

16. Wu WKK, Wong HPS, Luo SW, Chan K, Huang FY, Hui MKC, Lam EKY, Shin VY, Ye YN, Yang YH, Cho CH (2005) 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Research 65(12):5272-7. (equal contribution)