Research
WU, Ka Kei William
Name : WU, Ka Kei William 胡嘉麒
Title : Associate Professor (Non-clinical)
Home Department :  Anaesthesia and Intensive Care
Email : wukakei@cuhk.edu.hk
Website : www.cuhk.edu.hk/med/ans/prof_william_wu.htm

Biography:

William Wu received basic medical science education at HKU during his MMedSc and MPhil studies and obtained PhD in Medical Sciences from CUHK in 2009. He received post-doctoral training and was later appointed as Research Assistant Professor in the Institute of Digestive Disease, CUHK. He joined the Department of Anaesthesia and Intensive Care as Assistant Professor (Non-clinical) in 2014 and was promoted to Associate Professor (Non-clinical) in 2018. His research interests include cancer biology & genomics, infection/sepsis, and pain mechanism. As of May 2021, he has published over 310 articles in peer-reviewed journals and 6 book chapters, with over 15,000 citations and an h-index of 59 (Scopus). He was conferred the Young Researcher Award by CUHK, the First-class Higher Education Outstanding Scientific Research Output Award (Natural Science) by the Ministry of Education, and the Second-class State Natural Science Award. He was also admitted as a Fellow of three Medical Royal Colleges (FRCPath, 2014; FRCP Edin, 2018; FRCPS Glasg, 2019). As Principal Investigator, he has presided over 20 million HK dollars of external funding, including 1 NSFC, 3 SZSTI Basic Research Programs, 3 RGC-ECS/GRF and 5 HMRF/RFCID.

Specialised Research Area(s):

  • Cancer Biology and Genomics
  • Sepsis and ICU-related Infections
  • Autophagy
  • Microbiome
  • Evolutionary Medicine

Selected Publications:

1. Li Q, Hu W, Liu WX, Zhao LY, Huang D, Liu XD, Chan H, Zhang Y, Zeng JD, Coker OO, Kang W, Ng SSM, Zhang L, Wong SH, Gin T, Chan MTV, Wu JL, Yu J, Wu WKK (2021) Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase. Gastroenterology 160(4):1179-1193.

2. Huang D, Wang X, Liu Y, Huang Z, Hu X, Hu W, Li Q, Chan H, Zou Y, Ho IHT, Wang Y, Cheng ASL, Kang W, To KF, Wang MHT, Wong SH, Yu J, Gin T, Zhang Q, Li Z, Shen J, Zhang L, Chan MTV, Liu X, Wu WKK (2021) Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Briefings in Bioinformatics doi: 10.1093/bib/bbab040.

3. Li Z, Li X, Shen J, Tan H, Rong T, Lin Y, Feng E, Chen Z, Jiao Y, Liu G, Zhang L, Chan MTV, Wu WKK (2021) Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury. Briefings in Bioinformatics 22(2):1291-1296.

4. Li Z, Huang Z, Li X, Huang C, Shen J, Li S, Zhang L, Wong SH, Chan MTV, Wu WKK (2021) Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID-19-associated Guillain-Barré syndrome. Cell Proliferation doi: 10.1111/cpr.13024.

5. Joynt GM, Wu WKK (2020) Understanding COVID-19: What dose viral RNA load really mean? Lancet Infectious Diseases 20(6):635-636.

6. Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV, Leung CCH, Wu WKK (2020) Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Critical Care 24(1):47.

7. Ho J, Li X, Zhang L, Liang Y, Hu W, Yau JCW, Chan H, Gin T, Chan MTV, Tse G, Wu WKK (2019) Translational genomics in pancreatic ductal adenocarcinoma: a review with re-analysis of TCGA dataset. Seminars in Cancer Biology 55:70-77. 

8. Wang X, Li X, Zhang L, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T, Chan MTV, Wu WKK (2018) Oncogenes expand during evolution to withstand somatic amplification. Annals of Oncology 29(11):2254-2260.

9. Zhang L, Hu W, Cho CH, Chan FK, Yu J, Ross Fitzgerald J, Cheung CK, Xiao ZG, Shen J, Li LF, Li MX, Wu JC, Ling TK, Chan JY, Ko H, Tse G, Ng SC, Yu S, Wang MH, Gin T, Ashktorab H, Smoot DT, Wong SH, Chan MT, Wu WKK (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. Journal of Pathology 244(4):432-444. 

10. Wu WKK, Li X, Wang X, Dai RZW, Cheng ASL, Wang MHT, Kwong T, Chow TC, Yu J, Chan MTV, Wong SH (2017) Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification. Molecular Biology and Evolution 34(4):903-907.

11. Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MHT, Gin T, Chan MTV, Wu WKK (2016) Autophagy in sepsis: degradation into exhaustion? Autophagy 12(7):1073-82.

12. Luo MXM, Wong SH, Chan MTV, Yu L, Yu SSB, Wu F, Xiao Z, Wang X, Zhang L, Cheng ASL, Ng SSM, Chan FKL, Cho CH, Yu J, Sung JJY, Wu WKK (2015) Autophagy mediates HBx-induced nuclear factor-κB activation and release of IL-6, IL-8 and CXCL2 in hepatocytes. Journal of Cellular Physiology 230(10):2382-9. 

13. Wong SH, Sung JJY, Chan FKL, To KF, Ng SSM, Wang XJ, Yu J, Wu WKK (2013) Genome-wide association and sequencing studies on colorectal cancer. Seminars in Cancer Biology 23(6 Pt B):502-511. 

14. Wong XJ, Yu J, Wong, SH, Cheng ASL, Chan FKL, Ng SSM, Cho CH, Sung JJY, Wu WKK (2013) A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy. Autophagy 9(10):1500-08. 

15. Wu WKK, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FKL, Yu J, Sung JJY (2012) The autophagic paradox in cancer therapy. Oncogene 31(8):939-53. 

16. Wu WKK, Sakamoto KM, Milani M, Aldana-Masankgay G, Fan D, Wu K, Lee CW, Cho CH, Yu J, Sung JJY (2010) Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy. Drug Resistance Updates 13(3):87-92. 

17. Wu WKK, Cho CH, Lee CW, Wu YC, Yu L, Li ZJ, Wong CCM, Li HT, Zhang L, Ren SX, Che CT, Wu K, Fan D, Yu J, Sung JJY (2010) Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy 6(2):228-238. 

18. Wu WKK, Lee CW, Cho CH, Fan D, Wu K, Yu J, Sung JJY (2010) MicroRNA dysregulation in gastric cancer: A new player enters the game. Oncogene 29(43):5761-71.

19. Wu WKK, Sung JJY, To KF, Yu L, Chu KM, Yu J, Cho CH (2010) The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells. Journal of Cellular Physiology 223(1):178-86. 

20. Wu WKK, Sung JJY, Wu YC, Li ZJ, Yu L, Cho CH (2008) Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells. British Journal of Pharmacology 154(3):632-8. 

21. Wu WKK, Li GR, Wong HPS, Hui MKC, Tai EKK, Lam EKY, Shin VY, Ye YN, Li P, Yang YH, Luo JC, Cho CH (2006) Involvement of Kv1.1 and Nav1.5 in proliferation of gastric epithelial cells. Journal of Cellular Physiology 207(2):437-44.

22. Wu WKK, Wong HPS, Luo SW, Chan K, Huang FY, Hui MKC, Lam EKY, Shin VY, Ye YN, Yang YH, Cho CH (2005) 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Research 65(12):5272-7.