Research
Yao Xiaoqiang
Name : YAO Xiaoqiang 姚曉強
Title : Professor
Home Department :  School of Biomedical Sciences
Email : yao2068@cuhk.edu.hk
Website : http://www.sbs.cuhk.edu.hk/TeachingStaffDetails.asp?TE_Name=YAO%20Xiao%20Qiang

Biography:

Xiaoqiang Yao, Ph.D., is the Professor in the School of Biomedical Sciences, The Chinese University of Hong Kong. He is one of active scientists in the area of Ca2+ signaling and ion channels in cardiovascular system. His interest are mechanosensation, ion channel phosphorylation regulation, arteriosclerotic development, cardiac stem cells, and cancer cell drug resistance.

Specialised Research Area(s):

Ion channels and Ca2+ signaling

Selected Publications:

1. Ma, X., Chen, Z., Hua, D., He, D., Wang, L., Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X,, Zhang, F., Wang, T., Hong, T., Jin, L., Qi, X., Chen, S., Gu, X., Yang, D., Pan, Q., Zhu, Y., Chen, Y., Chen, D., Jiang, L., Han, X., Zhang, Y., Jin, J., & Yao, X. (2014). Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. The Proceedings of the National Academy of Sciences, U.S.A., 111(17), 6389-6394.

2. Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C. Y., Xu, Z., Chan, F. L., Yu, S., Chen, Y., Zhu, R., Lei, J., Jin, J., & Yao, X. (2012). Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. The Proceedings of the National Academy of Sciences, U.S.A.,109(40), 16282-16287.

3. Du, J., Wong, W. Y., Sun, L., Huang, Y., & Yao, X. (2012). Protein kinase G inhibits flow-induced Ca2+ entry in M1-CCD cells. Journal of the American Society of Nephrology, 23(7), 1172-1180.

4. Shen, B., Kwan, H. Y., Ma, X., Wong, C. O., Du, J., Huang, Y., & Yao, X. (2011). cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. Journal of Biological Chemistry, 286(22), 19439-19445.

5. Ma, X., Cao, J., Luo, J., Nilius, B., Huang, Y., Ambudkar, I. S., & Yao, X. (2010). Depletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane. Arterioscleroisis, Thrombosis,and Vascular Biology, 30(11), 2249-2255.

6. Kwan, H. Y, Shen, B., Ma, X., Kwok, Y. C., Huang, Y., Man, Y. B., Yu, S., & Yao X. (2009). TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells. Circulation Research, 104(5), 670-678.

7. Cheng, K. T., Leung, Y. K., Shen, B., Kwan, H. Y., Kwok, Y. C., Wong, C. O., Ma, X., Huang, Y., & Yao, X. (2008). CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Arterioscleroisis, Thrombosis, and Vascular Biology, 28913-918.

8. Yao, X., & Garland, C. J. (2005). Recent developments in vascular endothelial cell transient receptor potential channels. Circulation Research, 97(9), 853-863. 

9. Kwan, H. Y., Huang, Y., & Yao, X. (2004). Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G. The Proceedings of the National Academy of Sciences, U.S.A., 101(8), 2625-2630.

10. Yao, X., & Huang, Y. (2003). From nitric oxide to endothelial cytosolic Ca2+: a negative feedback control. Trends in Pharmacological Sciences, 24(6), 263-266.