Name : ZHANG Ning 張寧
Title : Assistant Professor
Home Department:  Orthopaedics and Traumatology
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Dr. Ning Zhang is currently an Assistant Professor in the Department of Orthopaedics & Traumatology at the Chinese University of Hong Kong (CUHK). Dr. Zhang earned his Ph.D. from CUHK and completed postdoctoral training at Stanford University in the Department of Orthopaedic Surgery. Dr. Zhang's career has been marked by over 45 publications in international peer-reviewed journals with 1000+ citations. As an orthopaedic researcher, Dr. Zhang's primary focus centers on innovative cell-based and tissue-engineering strategies designed to modulate bone and muscle regeneration. His passion is firmly rooted in uncovering novel targets and strategies for the diagnosis and treatment of these conditions.

Specialised Research Area(s):

  • Cell-based Therapies for Musculoskeletal Disorders
  • Tissue Regeneration Microenvironment Modulation
  • Bone-Muscle Interactions

Selected Publications: 

1. X Li, H Shen, M Zhang, V Teissier, E Huang, Q Gao, M Tsubosaka, M Toya, J Kushioka, CV Maduka, CH Contag, SKH Chow, N Zhang*, SB Goodman*. Glycolytic reprogramming in macrophages and MSCs during inflammation. Frontiers in Immunology. 14: 1199751; 2023.

2. M Zhang, B Shan, S Lin, J Xu, N Zhang*. Editorial: Nutrition and metabolism in musculoskeletal disorders. Frontiers in Nutrition. 10: 1269939; 2023.

3. H Hirata1, N Zhang1 (co-first author), M Ueno, D Barati, J Kushioka, HS Shen, M Tsubosaka, M Toya, TH Lin, E Huang, ZY Yao, JY Wu, S Zwingenberger, F Yang, SB Goodman. Ageing Attenuates Bone Healing by Mesenchymal Stem Cells in a Microribbon Hydrogel with a Murine Long Bone Critical-Size Defect Model. Immunity & Ageing. 19,14; 2022.

4. E Huang1, N Zhang1 (co-first author), EA Ganio, HS Shen, XP Li, M Ueno, T Utsunomiya, M Maruyama, Q Gao, N Su, ZY Yao, F Yang, B Gaudillière, SB Goodman. Differential dynamics of bone graft transplantation and mesenchymal stem cell therapy during bone defect healing in a murine critical size defect. Journal of Orthopaedic Translation. 36:64-74; 2022.

5. N Zhang, CW Lo, T Utsunomiya, M Maruyama, E Huang, C Rhee, Q Gao, ZY Yao, SB Goodman. PDGF-BB and IL-4 co-overexpression is a potential strategy to enhance mesenchymal stem cell-based bone regeneration. Stem Cell Research & Therapy. 12 (1), 1-11; 2021.

6. N Zhang, T Utsunomiya, TH Lin, Y Kohno, M Ueno, M Maruyama, E Huang, C Rhee, ZY Yao, SB Goodman. Mesenchymal Stem Cells and NF-κB Sensing Interleukin-4 Over-Expressing Mesenchymal Stem Cells Are Equally Effective in Mitigating Particle-Associated Chronic Inflammatory Bone Loss in Mice. Frontiers in Cell and Developmental Biology. 9:757830; 2021

7. M Ueno1, N Zhang1 (co-first author), H Hirata, D Barati, T Utsunomiya, HS Shen, TH Lin, M Maruyama, E Huang, ZY Yao, JY Wu, S Zwingenberger, F Yang, SB Goodman. Sex Differences in Mesenchymal Stem Cell Therapy with Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model. Frontiers in bioengineering and biotechnology. 9: 755964; 2021.

8. T Utsunomiya1, N Zhang1 (co-first author), TH Lin, Y Kohno, M Ueno, M Maruyama, C Rhee, E Huang, ZY Yao, SB Goodman. Different effects of intramedullary injection of mesenchymal stem cells during the acute versus chronic inflammatory phase on bone healing in the murine continuous polyethylene particle infusion model. Frontiers in Cell and Developmental Biology. 9, 329; 2021.

9. N Zhang, YN Chim, J Wang, RMY Wong, SKH Chow, WH Cheung. Impaired fracture healing in sarco-osteoporotic mice can be rescued by vibration treatment through myostatin suppression. Journal of Orthopaedic Research. 38 (2), 277-287; 2019.

10. N Zhang, SKH Chow, KS Leung, HH Lee, WH Cheung. An animal model of co-existing sarcopenia and osteoporotic fracture in senescence accelerated mouse prone 8 (SAMP8). Experimental Gerontology. 97: 1-8; 2017.