Huating WANG
Back
Title
Professor
Home Department
Orthopaedics and Traumatology
Email
huating.wang@cuhk.edu.hk
Office Phone No.
(852) 3763 6047
Office Address
Room 507, 5/F, Li Ka Shing Medical Sciences Building, Prince of Wales Hospital, Sha Tin
Website
https://cuhkwanglab.github.io/
ORCID ID
0000-0001-5474-2905
Web of Science
C-6719-2014
progress report
View
Research Interests
Specialised Research Area
Biography
Selected Awards
Selected Publications
Research Interests
  • Mechanistic study of skeletal muscle stem cell regulation in skeletal muscle regeneration, diseases and aging.
  • Development of intervention strategies for combating sarcopenia and enabling healthy aging.
Specialised Research Area

Skeletal muscle allows voluntary movement and plays a key role in regulating metabolism and homeostasis in the organism. Adult muscle stem cells, MuSCs, are responsible for muscle growth and regeneration. Responding to muscle injury, MuSCs are indispensable for the ensued regeneration by quickly activating to enter cell cycle, proliferate, and differentiate to form myofibers de novo. Deregulated MuSC activity contributes to the development of muscle diseases such as muscular dystrophy and also age-associated sarcopenia. The group led by Huating Wang dedicates their efforts to deciphering both the intrinsic and extrinsic mechanisms governing MuSC activity in both physiological and pathological settings, with the goal of discovering druggable targets for devising approaches for enhancing muscle regeneration, ameliorating muscle diseases, and slowing down muscle aging.

Biography

Huating Wang is currently a Professor at Li Ka Shing Institute of Health Sciences, Department of Orthopaedics and Traumatology (ORT), The Chinese University of Hong Kong (CUHK). She received her B.S degree in 1996 from Nanjing University, China and majored in Environmental Chemistry. In 1998 she moved to U.S.A. to pursue her Ph.D. degree at the Ohio State University (OSU) with the award of a Research Assistantship. She studied Molecular Virology under the mentorship of Dr. Louis Mansky and obtained her Ph.D. in 2004. She then remained at OSU since 2004 for her Postdoctoral training under the mentorship of Dr. Denis Guttridge with the support of a Postdoctoral Researcher Fellowship from The Comprehensive Cancer Center, OSU and later a F32 Postdoctoral Fellowship Award from National Institute of Health, U.S.A. In 2009, she moved to Hong Kong for an Assistant Professor position at Department of Obstetrics and Gynaecology, Faculty of Medicine, CUHK. She then moved to Department of ORT and was soon promoted to Associate Professor in 2015 and Full Professor in 2020.

The main research focus of her group is to study intrinsic and extrinsic regulation of skeletal muscle stem cells in muscle regeneration, diseases and aging. She has published over 90 papers as the corresponding author in journals such as Nature Communications, Science Advances, EMBO Journal, Cell Research, Nucleic Acids Research, and Genome Biology. She is one of the founders of the Chinese Society for Skeletal Muscle Research and an active member of the Chinese Society for Aging Research, the Chinese Society for Biophysics, and the Guangdong Society for Stem Cell Research. She serves on the editorial boards of journals including Skeletal Muscle, Life Medicine, and Journal of Translational Orthopaedics.

Selected Awards
  1. High Impact Publication Award, The Chinese University of Hong Kong (2023, 2024, 2025)
  2. Strategic Seed Funding for Collaborative Research Scheme, The Chinese University of Hong Kong (2022)
  3. Keystone Symposium Best Talk Award, USA (2018)
  4. H. Ho Stanford Visiting Professorship, The Chinese University of Hong Kong (2016)
  5. NIH Ruth L. Kirschestein National Research Service Award, USA (2006)
  6. OSU Cancer Center Postdoctoral Fellowship, USA (2004)
Selected Publications
  1. Li Y, Li C, Sun Q, Liu X, Chen F, Cheung Y, Zhao Y, Xie T, Chazaud B, Sun H, Wang H. Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis. Nature Communications. 2025;16(1):1324-. doi:10.1038/s41467-025-56474-w.
  2. Li Y, Li C, Zhou Q, Liu X, Qiao Y, Xie T, Sun H, Ong MTY, Wang H. Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia. Nature Communications. 2025;16(1):6207-. doi:10.1038/s41467-025-61403-y.
  3. Chen X, Yang F, Zhang S, Guo X, Zhao J, Qiao Y, He L, Li Y, Zhou Q, Ong MTY, Kwok CK, Sun H, Wang H. DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights. Genome Biology. 2025;26(1):269-. doi:10.1186/s13059-025-03753-w.
  4. Sun Q, Zhou Q, Qiao Y, Chen X, Sun H, Wang H. Pervasive RNA-binding protein enrichment on TAD boundaries regulates TAD organization. Nucleic Acids Research. 2025;53(1):1271. doi:10.1093/nar/gkae1271.
  5. Zhang Y, Zhao J, Chen X, Qiao Y, Kang J, Guo X, Yang F, Lyu K, Ding Y, Zhao Y, Sun H, Kwok CK, Wang H. DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1. Nature Communications. 2024;15(1):9890-. doi:10.1038/s41467-024-54000-y.
  6. Zhang S, Yang F, Huang Y, He L, Li Y, Wan YCE, Ding Y, Chan KM, Xie T, Sun H, Wang H. Author Correction: ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression. Nature Communications. 2023;14(1):5968-. doi:10.1038/s41467-023-41720-w.
  7. Zhao Y, Ding Y, He L, Zhou Q, Chen X, Li Y, Alfonsi MV, Wu Z, Sun H, Wang H. Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging. Science Advances. 2023;9(7). doi:10.1126/sciadv.abo1360.
  8. Qiao Y, Sun Q, Chen X, He L, Wang D, Su R, Xue Y, Sun H, Wang H. Author response: Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export. eLife. 2023;12. doi:10.7554/elife.82703.
  9. So KKH, Huang Y, Zhang S, Qiao Y, He L, Li Y, Chen X, Sham MH, Sun H, Wang H. seRNA PAM controls skeletal muscle satellite cell proliferation and aging through trans regulation of Timp2 expression synergistically with Ddx5. Aging Cell. 2022;21(8):e13673. doi:10.1111/acel.13673.
  10. Chen X, Xue G, Zhao J, Zhang Y, Zhang S, Wang W, Li Y, Yuan J, He L, Chan CY, Liu Y, Chen W, Zhao Y, Hu P, Sun H, Kwok CK, Wang H. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5’ UTR rG4 unwinding and Anp32e translation. Cell Reports. 2022;39(10):110927. doi:10.1016/j.celrep.2022.110927.
  11. Chen X, Yuan J, Xue G, Campanario S, Wang D, Wang W, Mou X, Liew SW, Umar MI, Isern J, Zhao Y, He L, Li Y, Mann CJ, Yu X, Wang L, Perdiguero E, Chen W, Xue Y, Nagamine Y, Kwok CK, Sun H, Muñoz-Cánoves P, Wang H. Translational control by DHX36 binding to 5’ UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nature Communications. 2021;12(1):5043-. doi:10.1038/s41467-021-25170-w.
  12. He L, Ding Y, Zhao Y, So KK, Peng XL, Li Y, Yuan J, He Z, Chen X, Sun H, Wang H. CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell. Stem Cell Reports. 2021;16(10):2442-2458. doi:10.1016/j.stemcr.2021.08.011.
  13. Li Y, Yuan J, Chen F, Zhang S, Zhao Y, Chen X, Lu L, Zhou L, Chu CY, Sun H, Wang H. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Nature Communications. 2020;11(1):2725-. doi:10.1038/s41467-020-16553-6.
  14. Zhao Y, Zhou J, He L, Li Y, Yuan J, Sun K, Chen X, Bao X, Esteban MA, Sun H, Wang H. MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nature Communications. 2019;10(1):5787-. doi:10.1038/s41467-019-13598-0.
  15. Zhou J, So KK, Li Y, Li Y, Yuan J, Ding Y, Chen F, Huang Y, Liu J, Lee W, Li G, Ju Z, Sun H, Wang H. Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells. Aging Cell. 2019;18(5):e12996. doi:10.1111/acel.12996.
  16. Chen F, Zhou J, Li Y, Zhao Y, Yuan J, Cao Y, Wang L, Zhang Z, Zhang B, Wang CC, Cheung TH, Wu Z, Wong CC, Sun H, Wang H. YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells. The EMBO Journal. 2019;38(10):EMBJ201899727-. doi:10.15252/embj.201899727.
  17. Zhou L, Sun K, Zhao Y, Zhang S, Wang X, Li Y, Lu L, Chen X, Chen F, Bao X, Zhu X, Wang L, Tang LY, Esteban MA, Wang CC, Jauch R, Sun H, Wang H. Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1. Nature Communications. 2015;6(1):10026-. doi:10.1038/ncomms10026.
  18. Wang L, Zhao Y, Bao X, Zhu X, Kwok YKY, Sun K, Chen X, Huang Y, Jauch R, Esteban MA, Sun H, Wang H. LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration. Cell Research. 2015;25(3):335-350. doi:10.1038/cr.2015.21.
  19. Zhao Y, Yang Y, Trovik J, Sun K, Zhou L, Jiang P, Lau TS, Hoivik EA, Salvesen HB, Sun H, Wang H. A novel wnt regulatory axis in endometrioid endometrial cancer. Cancer Research. 2014;74(18):5103-5117. doi:10.1158/0008-5472.CAN-14-0427.
  20. Lu L, Sun K, Chen X, Zhao Y, Wang L, Zhou L, Sun H, Wang H. Genome‐wide survey by ChIP‐seq reveals YY1 regulation of lincRNAs in skeletal myogenesis. EMBO Journal. 2013;32(19):2575-2588. doi:10.1038/emboj.2013.182.