Ronald WANG
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Title
Professor
Home Department
Obstetrics & Gynaecology
Email
ccwang@cuhk.edu.hk
Office Phone No.
(852) 3505 4267
Office Address
1/F, Old Block E, Department of Obstetrics & Gynaecology, Prince of Wales Hospital, Sha Tin
Website
https://www.obg.cuhk.edu.hk/about-us/our-staff/prof-wang-chi-chiu-ronald/
ORCID ID
0000-0002-3928-7278
Web of Science
C-6541-2014
progress report
Research Interests
  • Reproduction & Development
  • Clinical Trials, Cell models and Animal models
  • Multiomics and Bioinformatics
Specialised Research Area
  • Reproductive Medicine (endometriosis, miscarriage, implantation failure, polycystic ovary syndrome)
  • Developmental Biology (redox control, gene dosage)
  • Maternal Medicine (preeclampsia, gestational diabetes mellitus)
  • Fetal Medicine (fetal hypoxia, preterm, fetal growth restriction)
Biography

Ronald Wang is currently a Professor, Director of Chinese University of Hong Kong – Sichuan University Joint Reproductive Medicine Laboratory, and Deputy Director of Prenatal Genetic Diagnosis Centre in Department of Obstetrics & Gynaecology at The Chinese University of Hong Kong. Ronald joined the department after his MBBS degree with honours in 1994, and he received his first Ph.D. in Surgical Sciences from the Chinese University of Hong Kong in 1998 and his second Ph.D. in Genetics from Japan National Institute of Genetics in 2011. He has major research focus in studying Reproduction and Development. With wide range of experience in clinical and medical research and teaching, Ronald was appointed to the editorial boards and review panels of many important research funding agents and journals. He has worked on many research projects received a total of over HK$125 million research grants and owned over 27 patents. Ronald has published over 350 ISI articles on many acclaimed journals including JAMA, Ann Int Med, Nat Cell Biol, Nat Commun, Adv Sci, Gene Dev, Cell Research, PNAS, Angiogenesis, Hum Reprod Update, Hum Reprod, Mol Hum Reprod, and Fertil Steril. His success in translational O&G research has earned him multiple local and international scholarships and both research and innovation awards. He is also reviewer of many journals (including Lancet, BMJ, Hum Reprod, Fertil Steril, BJOG, FRBM, FASEB, J Path, Development, Physiol Genomics, etc) and grant agents (NSFC, JSIEC, NMRC, NCSR, OPUS, ZonMw, etc).

Selected Awards
  1. Social Impact Award and Merit, CUHK Entrepreneurship Competition, CUHK Alumni Affairs Office (2025)
  2. Gold Medal, Silicon Valley International Invention & Innovation Festival – SVIIF (2024)
  3. 2024 Silver Medal × 1, 2023 Silver Medal × 1, International Invention Fair in the Middle East (2023, 2024)
  4. 2024 Gold Medal × 1 and Silver Medal × 1, 2022 Silver Medal × 2, International Exhibition of Inventions Geneva (2022, 2024)
  5. 成果自然科學獎三等獎, 第五屆婦幼健康科學技術獎 (2023)
  6. 一等獎, 江西省人民政府江西省科學技術進步獎 (2022)
  7. 三等獎, 中華中醫藥學會的科學技術獎 (2021)
  8. 第二批引進類創新領軍人才, 江西省引進培養創新創業高層次人才, 雙千計劃 (2019)
  9. 科學技術獎一等獎, 中國中西醫結合學會 (2017)
  10. 科技進步獎 – 推廣類二等獎, 教育部高等學校科學研究優秀成果獎 (2015)
Selected Publications
  1. Chan HW, Wang CC, Yiu D, Chan L. Clinical outcomes and euploidy rates of embryos derived from zygotes with nonpronuclear (0PN) and monopronuclear (1PN) in IVF or ICSI cycles: A systematic review and meta-analysis. Human Reproduction Update. Published online June 4, 2026. doi:10.1093/humupd/dmag015.
  2. Shi Y, Yang Y, Guo X, Shi S, Li Q, Wang CC, Poon LC, Chung PW, Xia J, Wang Y, Lai X, Ni Y, Chen X, Wang Y. Blood-based biomarker discovery for early pregnancy loss using integrative multi-omics strategies. eBioMedicine. 2026;127:106253. doi:10.1016/j.ebiom.2026.106253.
  3. Shi Y, Wang CC, Yang Y, Li Q, Chung PW, Wang Y. The diagnostic accuracy of wearable digital technology in detecting fertility window and menstrual cycles: A systematic review and Bayesian network meta-analysis. npj Digital Medicine. 2026;9(1):139-. doi:10.1038/s41746-025-02320-8.
  4. Ayele AD, Azeze GG, Alemu BK, Wang Y, Wang CC. Evaluating the performance of maternal risk factors in predicting gestational diabetes mellitus: A systematic review and meta-analysis. BMJ Evidence-Based Medicine. 2025;0. doi:10.1136/bmjebm-2025-114065.
  5. Alemu BK, Wang CC, Poon LC, Wang Y. Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice. BMC Medicine. 2025;24(1):25. doi:10.1186/s12916-025-04516-x.
  6. Mou X, Li L, Liu X, Zhang A, He T, Rao B, Zhang J, Chen R, Spielmann M, Wang CC, Cong B, Fan X. Single-nucleus RNA sequencing reveals the mechanism of neonatal hypoxic–ischemic encephalopathy and the neuroprotection effects of salvianolic acid c. Engineering. 2025;55:269-290. doi:10.1016/j.eng.2025.09.010.
  7. Wu H, Yang Y, Zhao C, Lyu X, Li J, Lei J, Liu M, Hu X, Deng Y, He Y, Wang Y, Peng Z, Zhang Y, Zhang H, Wang Q, Shen H, Zhang Y, Yan D, Ma RCW, Wang CC, Ma X. Preconception hypoglycemia and adverse pregnancy outcomes in Chinese women aged 20-49 years: A retrospective cohort study in China. PLOS Medicine. 2025;22(7):e1004667. doi:10.1371/journal.pmed.1004667.
  8. Tlaye KG, Woldeamanuel GG, Wong KCY, Chen L, Zheng R, So PK, Wang X, Nguyen-Hoang L, Zhong M, So HC, Leung BW, Huang Y, Wang Y, Poon LC, Wang CC. Pharmacogenomics and pharmacokinetics of aspirin in preeclampsia prevention. Circulation Research. 2025;137(1):69-82. doi:10.1161/circresaha.124.325699.
  9. Woldeamanuel GG, Tlaye KG, Wang X, Nguyen-Hoang L, Zhou Q, Wang Y, Leung BW, Wang Y, Poon LC, Wang CC. Platelets in preeclampsia: An observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape. BMC Medicine. 2025;23(1):346-. doi:10.1186/s12916-025-04132-9.
  10. Liu BHM, Lin Y, Long X, Hung SW, Gaponova A, Ren F, Zhavoronkov A, Pun FW, Wang CC. Utilizing AI for the identification and validation of novel therapeutic targets and repurposed drugs for endometriosis. Advanced Science. 2025;12(5):e2406565. doi:10.1002/advs.202406565.
  11. Li Y, Hung SW, Zheng X, Ding Y, Zhang T, Tan Z, Zhang R, Lin Y, Song Y, Wang Y, Wang CC. Melatonin inhibits endometriosis growth via specific binding and inhibition of EGFR phosphorylation. Journal of Pineal Research. 2025;78:e70022. doi:10.1111/jpi.70022.
  12. Alemu BK, Wang CC, Li L, Zhu Z, Li Q, Wang Y. Effect of preconception antibiotics exposure on female reproductive health and pregnancy outcomes: A systematic review and meta-analysis. eClinicalMedicine. 2024;78:102935. doi:10.1016/j.eclinm.2024.102935. (Review)
  13. Hu H, Ma J, Peng Y, Feng R, Luo C, Zhang M, Tao Z, Chen L, Zhang T, Chen W, Yin Q, Zhai J, Chen J, Yin A, Wang CC, Zhong M. Thrombospondin-1 regulates trophoblast necroptosis via NEDD4-mediated ubiquitination of TAK1 in preeclampsia. Advanced Science. 2024;11(21):e2309002. doi:10.1002/advs.202309002.
  14. Gao L, Mathur V, Tam SKM, Zhou X, Cheung MF, Chan LY, Estrada-Gutiérrez G, Leung BW, Moungmaithong S, Wang CC, Poon LC, Leung D. Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal-fetal interface following SARS-CoV-2 infection. Nature Cell Biology. 2023;25(7):1047-1060. doi:10.1038/s41556-023-01169-x.
  15. Gao JS, Ma HL, Wang CC, Xie T, Wu XK. Acupuncture and doxylamine-pyridoxine for nausea and vomiting in pregnancy. Annals of Internal Medicine. 2024;177(2):267-268. doi:10.7326/L23-0427. (Letter)
  16. Wu X, Wang CC, Cao Y, Li J, Li Z, Ma H, Gao J, Chang H, Zhang D, Cong J, Wang Y, Wu Q, Han X, Chung PWJ, Li Y, Zheng X, Chen L, Zeng L, Borchert A, Kuhn H, Chen ZJ, Ng EHY, Stener-Victorin E, Zhang H, Legro RS, Mol BWJ, Shi Y. Novel genetic risk and metabolic signatures of insulin signaling and androgenesis in the anovulation of polycystic ovary syndrome. Engineering. 2023;23:103-111. doi:10.1016/j.eng.2022.08.013.
  17. Li J, Wu Q, Ng EHY, Mol BWJ, Wu XK, Wang CC. Effects of medicines and supplements on spontaneous pregnancy and semen parameters in male infertility: A systematic review update and network meta-analysis. Engineering. 2022;16:198-209. doi:10.1016/j.eng.2021.07.009. (Review)
  18. Donega V, van der Geest AT, Sluijs JA, van Dijk RE, Wang CC, Basak O, Pasterkamp RJ, Hol EM. Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors. Nature Communications. 2022;13(1):1036. doi:10.1038/s41467-022-28626-9.
  19. Wu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, Hou LH, Hu ZX, Shao XG, Ge J, Zhang JF, Xue HY, Xu XF, Liang RN, Ma HX, Yang HW, Li WL, Huang DM, Sun Y, Hao CF, Du SM, Yang ZW, Wang X, Yan Y, Chen XH, Fu P, Ding CF, Gao YQ, Zhou ZM, Wang CC, Wu TX, Liu JP, Ng EHY, Legro RS, Zhang H; PCOSAct Study Group. Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: A randomized clinical trial. JAMA. 2017;317(24):2502-2514. doi:10.1001/jama.2017.7217.
  20. Kai Y, Wang CC, Kishigami S, Kazuki Y, Abe S, Takiguchi M, Shirayoshi Y, Inoue T, Ito H, Wakayama T, Oshimura M. Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance. Cell Research. 2009;19:247-258. doi:10.1038/cr.2008.305.